eural plasticity, hearing loss and tinnitus: changes in tonotopic maps of the auditory cortex
Completed
- Conditions
- hearing losstinnitus10019243
- Registration Number
- NL-OMON40455
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
No hearing loss or reported tinnitus (controls, n=40)
Hearing loss (Hearing loss group, n=40)
Tinnitus (Hearing loss and tinnitus group, n=40)
< 30 dB difference between both ears for all the standard audiometric frequencies
Adults (18 - 75 yrs.)
No contraindications for MRI
Exclusion Criteria
Non-compliance with inclusion criteria
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary objective is to measure, characterize, and quantify the amount of<br /><br>neural plasticity, described as reorganisation of tonotopic maps in the<br /><br>auditory cortex using fMRI. Statistical assessments will be carried out to<br /><br>determine whether tonotopic maps differ in groups of subjects with hearing loss<br /><br>and subjects with hearing loss and tinnitus, both compared to normal hearing<br /><br>controls. </p><br>
- Secondary Outcome Measures
Name Time Method <p>In addition to the primary objective, the secondary objective is to measure the<br /><br>relation between the type of hearing loss (a steep-sloping and gradual-sloping<br /><br>hearing loss, respectively) and the degree of tonotopic reorganization.<br /><br>Statistical assessments will be carried out whether tonotopic maps differ<br /><br>between the groups of subjects with a steep-sloping hearing loss and subjects<br /><br>with a gradual-sloping hearing loss. Both groups will be compared to normal<br /><br>hearing controls.</p><br>