Effect of levetiracetam and topiramate in infantile spasms
Phase 2
Recruiting
- Conditions
- Infantile spasms.Other generalized epilepsy and epileptic syndromes
- Registration Number
- IRCT20091027002639N21
- Lead Sponsor
- Yazd University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age range of 2 months-1 year
Having infantile spasms based on definition of the International League Against Epilepsy
Resistance of their seizure to treatment of 2 mg/kg/day prednisolone for two months
Not used of other antiepileptic drugs
Exclusion Criteria
Discontinuation of levetiracetam and topiramate usage for more than one week
Allergy to levetiracetam and topiramate
Irregular drugs usage
Not returning for follow up
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Daily frequency of seizure. Timepoint: Before and after three months of treatment. Method of measurement: Asking from patient parents.;Treatment response. Timepoint: Before and after three months of treatment. Method of measurement: Asking from patient parents.
- Secondary Outcome Measures
Name Time Method Frequency of more than 50 % of reduction in daily frequency of seizure. Timepoint: Before and three months after treatment. Method of measurement: Asking from parents of patient.;Clinical side effects. Timepoint: During three months of treatment. Method of measurement: Asking from parents of patient.