A randomized controlled study of 'Jingjin' Acupotomy in the treatment of KOA and its neuroimmune mechanism
- Conditions
- Knee osteoarthritis
- Registration Number
- ITMCTR2000003436
- Lead Sponsor
- The Third Affiliated Hospital of Guangzhou University of traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Patients aged over 50 years;
2. The frequency of joint pain in the last month was more than 1 / 2 for patients with a duration of at least 6 months;
3. Patients with classic Kellgren Lawrence (K-L) grading of grade I to III;
4. The patients whose pain degree needs to meet the VAS score >= 5.0, and the effect of non steroidal anti-inflammatory drugs or physical therapy is not good;
5. Patients who did not receive glucocorticoid injection in the past three months;
6. Patients who did not receive sodium hyaluronate injection in the past year;
7. Patients signing informed consent;
8. Patients who can meet the diagnostic criteria of osteoarthritis set by American College of Rheumatology (ACR).
1. Musculoskeletal system:
Pain caused by definite trauma or sports injury in the past three months;
Mechanical or pathological fracture;
Knee pain caused by lumbar disease;
Knee pain caused by hip disease;
In the past half a year, knee implant operation;
Infectious, rheumatic, rheumatoid, ankylosing spondylitis and reactive arthritis;
Pain of knee caused by gout and abnormal metabolism of calcium and phosphorus;
Severe joint swelling;
Rupture of anterior and posterior cruciate ligament or collateral ligament;
Simple fasciitis or soft tissue strain;
Polymyositis, dermatomyositis and other immune system diseases;
2. General condition:
Mental disorders such as severe anxiety or depression;
Serious cardiovascular and cerebrovascular diseases;
Recent cardiovascular and cerebrovascular events in the past six months;
The function of liver and kidney was abnormal;
Allergic constitution;
Malignant tumor, bleeding disease, etc.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method VAS;Lysholm;WOMAC;
- Secondary Outcome Measures
Name Time Method Adverse events;