The Effects of Intravenous Lidocaine Infusion During and After Major Abdominal Pediatric Surgery. A Randomized Double-blinded Study
Overview
- Phase
- Phase 3
- Intervention
- Lidocaine Infusion
- Conditions
- Elective Major Abdominal Surgery
- Sponsor
- Mansoura University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Blood pressure
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
In this study, the investigators hypothesized that perioperative i.v. infusion of lidocaine in major abdominal pediatric surgery, may have a beneficial effect on hemodynamic and hormonal responses. Also, it could decrease the hospital stay, opioid requirement and hasten return of bowel function.
Detailed Description
The inflammatory response after major abdominal surgery is of great importance for patients, physicians and perioperative medicine1. Perioperative excessive stimulation of the inflammatory and hemostatic systems may result in development of postoperative ileus, ischemia-reperfusion syndromes, hypercoagulation syndromes (e.g. deep venous thrombosis) and pain excessive inflammatory response such as impaired gastrointestinal motility, so modulation of inflammatory responses may decrease severity of such complications 2,3. Intravenous lidocaine, a local anesthetic, has been shown to improve postoperative analgesia, reduce postoperative opioid requirements, accelerate postoperative recovery of bowel function, attenuate postoperative fatigue, reduced the duration of hospitalization, and facilitate acute rehabilitation in patients undergoing laparoscopic abdominal surgery 4. Administration of local anesthetics to epidural space has analgesic effect, blunt stress response; provide rapid mobilization, early extubation with rapid recovery of bowel function 5. However, insertion of an epidural catheter carries risks especially in pediatric populations. So, systemic lidocaine may become another strategy for improving perioperative outcome which is safe and effective2.
Investigators
Mohamed R El Tahan
Associate Professor of Anesthesiology
Mansoura University
Eligibility Criteria
Inclusion Criteria
- •Pediatric
- •Abdominal surgery
- •ASA class I and II
Exclusion Criteria
- •history of hepatic diseases
- •history of cardiac diseases
- •history of renal diseases
- •allergy to local anesthetics
Arms & Interventions
group L
Lidocaine group
Intervention: Lidocaine Infusion
group P
Placebo group
Intervention: saline Infusion
Outcomes
Primary Outcomes
Blood pressure
Time Frame: for 2hrs after infusion
Secondary Outcomes
- Plasma Cortisol(for 24 hrs after infusion)
- Serum lidocaine(6 hrs after infusion)
- Heart rate (HR)(for 6 hrs after infusion)
- Pain scales(24 hrs postoperative)