Factor V Leiden Mutation and Implantation Failure
Completed
- Conditions
- Infertility
- Registration Number
- NCT00194350
- Lead Sponsor
- University of Pennsylvania
- Brief Summary
The purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in IVF. The specific condition to be studied is the presence or absence of the Leiden mutation of the Factor V gene.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 399
Inclusion Criteria
- Women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization
- Transfer of at least 2 fresh embryos of Grade 2 (preembryo with blastomeres of equal size and <=10% cytoplasmic fragmentation) or better
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Exclusion Criteria
- Infertility due to uterine anatomic defect
- Current use of anticoagulant medication, such as heparin or aspirin
- Known presence of any other condition associated with increased risk of thrombosis
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Pennsylvania Reproductive Research Unit
🇺🇸Philadelphia, Pennsylvania, United States