The Interactive Physical and Cognitive Exercise System

Not Applicable

• Conditions: Alzheimer Disease, Early Onset; Aging; Neurocognitive Disorder; MCI; Cognitive Change; Mild Cognitive Impairment; Cognitive Impairment
• Interventions: Behavioral: physical exercise alone (PES) first; Device: cognitive exercise alone (iCE) first; Device: interactive Physical and Cognitive Exercise (iPACES™)

• Registration Number: NCT03069391
• Lead Sponsor: Union College, New York

Brief Summary

This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise. In particular, this study will investigate the possible benefits of physical exercise (such as pedaling an under-table stationary elliptical) or mental exercise (such as playing a videogame on a portable tablet), or combining these activities together (as in the iPACES™ exergame).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-02-07
• Study First Submitted QC: 2017-02-27
• Study First Posted: 2017-03-03
• Study Start: 2017-03-04
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-29
• Last Update Posted: 2020-03-31
• Primary Completion: 2022-06-30
• Study Completion: 2022-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• co-residing older adults (e.g., spouses, partners, roommates, relatives)
• both at least 50 years of age
• normative/typical cognitive function or those with Mild Cognitive Impairment (MCI) or mild Neurocognitive Disorder (mNCD) or early Alzheimer's disease
• adequate vision and dexterity for on-screen assessments
• able to pedal an under-table elliptical
• permission of primary care provider and cardiologist (if applicable)

Exclusion Criteria

• history of seizure
• Parkinson's disease
• significant dementia/memory loss

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
physical, cognitive, then interactive	physical exercise alone (PES) first	physical exercise alone (PES) first, then iPACES
cognitive, physical, then interactive	interactive Physical and Cognitive Exercise (iPACES™)	cognitive exercise alone (iCE) first, then iPACES
physical, cognitive, then interactive	interactive Physical and Cognitive Exercise (iPACES™)	physical exercise alone (PES) first, then iPACES
cognitive, physical, then interactive	cognitive exercise alone (iCE) first	cognitive exercise alone (iCE) first, then iPACES

Primary Outcome Measures

Name	Time	Method
executive function composite score	change over time from baseline to 3 months	comprised of scores from Stroop, Trails, and Flanker

Secondary Outcome Measures

Name	Time	Method
Sit-Stand Test	change over time in score from baseline to 3 months	scored performance on time and technique to move from sitting on floor to standing
brain-derived neurotrophic factor (BDNF)	change over time from baseline to 3 months	change in amount in saliva sample over time (pg/ml) per ELISA

Trial Locations

Locations (1)

Healthy Aging & Neuropsychology Lab @ Union College; 🇺🇸 Schenectady, New York, United States