Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Management of Severe Preeclampsia and Eclampsia.
- Conditions
- Severe Pre-eclampsiaEclampsia
- Interventions
- Drug: Use of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia
- Registration Number
- NCT06126068
- Lead Sponsor
- Federal Teaching Hospital Abakaliki
- Brief Summary
Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria.
To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in severe preeclampsia and recurrent fits in eclampsia in a low resource setting.
A prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at the Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Sociodemographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted.
- Detailed Description
Background: Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria.
Objectives: To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in patients with severe preeclampsia and recurrent fits in eclampsia in a low resource setting like ours.
Methods: This was a prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at Alex Ekwueme Federal University Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Social demographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted. Data were collated, tabulated and analyzed using the statistical package for social sciences (SPSS) software (version 22, Chicago II, USA)
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
- Pregnant women with severe preeclampsia
- Pregnant women with eclampsia
- Signing of informed consented to participate in the study.
- Refusal of consent,
- Gestational age < 28 weeks
- Received magnesium sulphate prior to presentation
- mild preeclampsia
- chronic hypertension in pregnancy
- Medical or Obstetrical complication of pregnancy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description first arm - Loading dose of magnesium sulfate Use of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia This arm received Loading dose of magnesium sulfate only. those that developed complication in each arm were managed according to departmental protocol. 2. Pritchard regimen Use of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia This arm received the full dose of magnesium sulfate regimen by Pritchard. those that developed complication in each arm were managed according to departmental protocol also.
- Primary Outcome Measures
Name Time Method Incidence of convulsions During the intervention percentage of fits in severe pre-eclampsia and recurrence of fits in eclampsia
- Secondary Outcome Measures
Name Time Method Drug toxicity During the intervention number of neonatal asphyxia, respiratory depression, loss of tendon reflex and cardiac arrest.
Trial Locations
- Locations (1)
Federal Teaching Hospital, Abakaliki
🇳🇬Abakaliki, Ebonyi, Nigeria