Causal Relationship Between Dry Eye and Accommodative Spasm

Recruiting

• Conditions: Dry Eye

• Registration Number: NCT05120401
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

To investigate the causal relationship of Sicca dry eye patients with presbyopic refractive error and accommodative spasm.

Detailed Description

Dry eye is a disease of the ocular surface. Severe dry eye produce symptom of discomfort in and around the eye that drastically affect life quality of the patient. OSDI index is retrieve from a questionnaire specific for these dry eye symptoms, it is an internationally accepted level to reveal the severity of Dry eye disease. One part of the symptom is pain and soreness around the eye. Hyperalgesia is an increase response to a stressful/ noxious stimulus whereas allodynia is a painful response to a normally innocuous stimulus. Our hypothesis state that Sicca Dry eye upregulated inflammatory cytokine in the eye has pre-sensitized the nociceptor nerve fiber in the cornea and orbit, therefore the normally innocuous effort of accommodation and ciliary muscle contraction produce intolerable retro-orbital eye pain, which drives the patient to seek medical attention, on presentations these patient show an elevated OSDI and Pain Index (PI).

Study Timeline

• Status Verified: 2021-11
• Study First Submitted: 2021-11-03
• Study First Submitted QC: 2021-11-03
• Last Update Submitted: 2021-11-03
• Study Start: 2021-11-05
• Study First Posted: 2021-11-15
• Last Update Posted: 2021-11-15
• Primary Completion: 2024-07-20
• Study Completion: 2025-10-15

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• dry eye

Exclusion Criteria

• under 20 year old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improve of dry eye / OSDI	30 days	OSDI improve

Trial Locations

Locations (1)

Far Eastern Memorial Hospital; 🇨🇳 New Taipei City, Taiwan