Weaning is Winning? (WeWin Study)
- Conditions
- Parenteral NutritionIntestinal Failure
- Interventions
- Other: Weaning off Parenteral Nutrition
- Registration Number
- NCT06525753
- Lead Sponsor
- The Hospital for Sick Children
- Brief Summary
We propose a multicenter prospective study on pediatric patients with intestinal failure (IF) who weaned off parenteral nutrition (PN).
- Detailed Description
Children with IF depend on PN. This is associated with frequent and various complications such as metabolic bone disease, micronutrient deficiencies and abnormal body composition. Due to advancements in care, many patients with IF are able to wean off PN; they are so called PN graduates. It is currently not well known how often complications do occur after weaning off PN, and which patients are at highest risk of developing these complications.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
- Parenteral Nutrition graduates for at least 1 year, with a history of intestinal failure.
- Age <18 years at time of inclusion.
Exclusion criteria:
- No consent provided.
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Erasmus Weaning off Parenteral Nutrition Patients recruited from the Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands SickKids Weaning off Parenteral Nutrition Patients recruited from the Hospital for Sick Children (SickKids), Toronto, Canada
- Primary Outcome Measures
Name Time Method Complications From 1 year after weaning off PN to 18 years of age Assess the frequency of nutritional complications including poor growth, micronutrient deficiencies, poor bone health, abnormal body composition, and delayed pubertal development in PN graduates.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
The Hospital for Sick Children🇨🇦Toronto, Ontario, Canada