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Clinical Trials/NCT06704867
NCT06704867
Enrolling by Invitation
N/A

High Flow Nasal Cannula Compared to Standard Oxygen Therapy for Endoscopic Ultrasound Procedure in High Risk Patients on Recovery Time and Procedural Conditions

Mayo Clinic2 sites in 1 country200 target enrollmentJuly 14, 2025

Overview

Phase
N/A
Intervention
Standard oxygen therapy
Conditions
Endoscopic Ultrasound
Sponsor
Mayo Clinic
Enrollment
200
Locations
2
Primary Endpoint
Decrease recovery time
Status
Enrolling by Invitation
Last Updated
3 months ago

Overview

Brief Summary

The purpose of the study is to evaluate the use of high flow nasal cannula versus standard oxygen therapy for high-risk patients undergoing endoscopy procedures.

Detailed Description

Patients with a higher BMI are at greater risk for lower oxygen levels which can delay the endoscopy procedure. This research is being conducted to find out if high risk patients will have a shorter recovery time and improved procedural conditions with a high flow nasal cannula versus standard oxygen therapy.

Registry
clinicaltrials.gov
Start Date
July 14, 2025
End Date
October 1, 2026
Last Updated
3 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Bhargavi Gali, M.D.

Principal Investigator

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

  • All patients age 18 years and older who present to Gonda 2 procedural area for Endoscopic ultrasound (EUS) with or without endoscopy (EGD)/biopsy/tissue sampling. with BMI ≥ 35 kg/m2 (BMI within the past 6 months in electronic medical records or at current procedure) who are able to consent will be approached for potential enrollment.

Exclusion Criteria

  • Need for general anesthesia for the procedure instead of the standard monitored anesthesia care.
  • Patients undergoing combined procedure: Therapeutic EUS/combined procedures including EUS/ERCP, EUS/colonoscopy
  • Patients on home oxygen therapy, or the diagnosis of "severe COPD"
  • Patients with existing tracheostomy
  • Inpatients undergoing EUS
  • Inability to consent
  • Cognitive impairment
  • Blocked nasal passages
  • Trauma/previous surgery to the nasopharynx
  • Irregularities of the nose, face, or airway such that HFNC cannot be properly fitted

Arms & Interventions

Standard oxygen therapy

Standard oxygen therapy will be initiated utilizing 2-4 liters of oxygen with a nasal cannula.

High Flow Nasal Cannula

A high flow oxygen device with 100% FiO2 will be initiated prior to endoscopic ultrasound.

Intervention: High flow nasal cannula

Outcomes

Primary Outcomes

Decrease recovery time

Time Frame: 4 hours

Time measured in minutes for participants to enter post anesthesia care until the nurse marks "ready for discharge" in the medical record.

Secondary Outcomes

  • Improve procedural conditions(1 hour)

Study Sites (2)

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