High Flow Nasal Cannula Oxygen During Sedation for Video-assisted Thoracoscopic Surgery

Phase 2

• Conditions: Respiratory Failure; Chronic Obstructive Pulmonary Disease
• Interventions: Combination Product: CONTROL; Combination Product: High flow nasal cannula

• Registration Number: NCT04520568
• Lead Sponsor: Alexandria University

Brief Summary

High-flow nasal cannula (HFNC) is a device that delivers10 to 70 L min-1 of heated, humidified 100% oxygen via nasal route. It provides positive airway pressure, decreases dyspnea, decreases the work of breathing, and improves comfort

Detailed Description

Beneficial effects of the HFNC system have been assessed based on 3 physiologic conditions: decreased dead space, a high concentration of inspiratory oxygen, and positive pressure in the oro-laryngeal cavity.Studies have shown that it improves oxygenation in various perioperative settings such as the apneic patients, patients with respiratory failure , and patients undergoing bronchoscopy

Study Timeline

• Status Verified: 2020-08
• Study Start: 2020-08-01
• Study First Submitted: 2020-08-16
• Study First Submitted QC: 2020-08-19
• Last Update Submitted: 2020-08-19
• Study First Posted: 2020-08-20
• Last Update Posted: 2020-08-20
• Primary Completion: 2020-11-10
• Study Completion: 2020-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA physical status II and III,
• undergoing VATS

Exclusion Criteria

• refusal of patients
• extrem of age

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	CONTROL	induction of general anaesthesia will be done using 2 mg/kg propofol and 1 µg/kg fentanyl. Double lumen tube will be facilitated by cisatracurium 0.2 mg/kg. Anaesthesia will be maintained with isoflurane 0.8 %-1% in 100% oxygen and maintenance dose of cisatracurium 0.02 mg/kg when needed. At the end of surgery, residual neuromuscular paralysis will be antagonized with neostigmine 0.05 mg/kg and atropine 0.01 mg/kg.
HFNC group	High flow nasal cannula	For HFNC group, F\&P AIRVOTM 2 will be adjusted to give the patients the oxygen flow at 50L/min and the FiO2 at 1.0.Then after three minutes of preoxygenation, sedation will be conducted by giving 25 µg fentanyl and a bolus of 1 mg/kg propofol followed by continuous infusion of propofol using a target-controlled infusion system (TCI pump TE371; Terumo Corporation, TokyoJapan).

Primary Outcome Measures

Name	Time	Method
arterial partial pressures of oxygen	two hours	an arterial blood sample will be taken after induction of anaesthesia then every 10 min till the end of the operation.
pH measurement	two hours	an arterial blood sample will be taken after induction of anaesthesia then every 10 min till the end of the operation.

Trial Locations

Locations (1)

Rehab Abd Elraof Abd Elaziz; 🇪🇬 Alexandria, Egypt