High flow humidified nasal Oxygen to PrEvent desaturation FOR labouring people using remifentanil PCA (The HOPE-for-REMI study)

Not Applicable

Recruiting

• Conditions: Pregnancy; Pain relief; Anaesthesiology - Anaesthetics; Anaesthesiology - Pain management; Respiratory - Normal development and function of the respiratory system; Reproductive Health and Childbirth - Childbirth and postnatal care

• Registration Number: ACTRN12622000551796
• Lead Sponsor: Department of Anaesthesia, The Royal Women's Hospital - Parkville

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

People (20 in each group) in labour, expecting live birth, term pregnancy more than or equal to 37 weeks gestation, singleton pregnancy, no cardiac or respiratory disease, no previous caesarean section

Exclusion Criteria

Second stage of labour, significant nasal pathology, severe systemic disease (American Society of Anesthesiologists (ASA) physical status score of 3 or more), preeclampsia or sepsis, opioid allergy, inability to understand protocol instructions, substance abuse disorder, any administration of intramuscular opioid in the last 24 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxygen saturation less than or equal to 94%. <br>Oxygen saturations and oxygen reserve index will be measured using a Masimo Radical-7 touch pulse co-oximeter. [ Oxygen saturation will be measured continuously throughout protocol. Saturation less than 94% will be considered a desaturation episode at which time the lowest recorded saturation value and duration of desaturation will be recorded. ];Heart rate less than 40 beats per minute. This will be measured using a Masimo Radical-7 touch pulse co-oximeter. [ Heart rate will be measured continuously throughout protocol.];Oxygen reserve index. Oxygen saturations and oxygen reserve index will be measured using a Masimo Radical-7 touch pulse co-oximeter. [ Oxygen reserve index will be measured continuously throughout protocol. It will be specifically recorded one minute, 30 seconds and 10 seconds prior to any desaturation episode (oxygen saturation less than or equal to 94%)]