Genetic and Phenotypic Characteristics of Mitral Valve Prolapse

Nantes University Hospital3 sites in 1 country1,000 target enrollmentDecember 2010

ConditionsMitral Valve Prolapse Genetic Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Mitral Valve Prolapse
Sponsor: Nantes University Hospital
Enrollment: 1000
Locations: 3
Primary Endpoint: MVP defined by a superior displacement of at least 2 mm
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.

Detailed Description

After clinical identification of patients with MVP, doctors organize 1st degree relative familial screening. A comprehensive echocardiography was carried out along with clinical examination. All echo data were stored for off-line analysis by a sonographer in our Core-lab. Blood was sample at the time of echocardiography in adult patients for DNA analyses. Follow-up for mitral valve changes will be performed after 5 years.

Registry

clinicaltrials.gov

Start Date

December 2010

End Date

December 2021

Last Updated

4 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Nantes University Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients of any age
•with typical mitral valve prolapse
•relatives examined during familial screening

Exclusion Criteria

•Refusal of the patient

Outcomes

Primary Outcomes

MVP defined by a superior displacement of at least 2 mm

Time Frame: At Day 0

MVP defined by a superior displacement of at least 2 mm

Secondary Outcomes

Comprehensive mitral valve apparatus characterization per size of items (leaflets, chordae, annulus)(At Day 0)
Comprehensive mitral valve apparatus characterization per other items (papillary muscle, ventricles)(At Day 0)
Comprehensive mitral valve apparatus characterization per size of items (ventricle and atrium sizes)(At Day 0)
Comprehensive mitral valve apparatus characterization per size of items(At Day 0)