Genetic Basis of Mitral Valve Prolapse
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mitral Valve Prolapse
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 1500
- Locations
- 1
- Primary Endpoint
- Discovery of the genetic basis of Mitral Valve Prolapse
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.
Detailed Description
This is a genome-wide association study.
Investigators
Robert A. Levine, MD
Cardiologist
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Mitral valve prolapse
Exclusion Criteria
- •Other mitral valve diseases
Outcomes
Primary Outcomes
Discovery of the genetic basis of Mitral Valve Prolapse
Time Frame: 5 years
Genome-wide association