Effects of Red Ginseng on Gastrointestinal Symptoms and Microbiota After Surgery for Gastrointestinal Cancer
- Conditions
- Stomach CancerColorectal CancerPancreatobiliary Cancer
- Registration Number
- NCT06561516
- Lead Sponsor
- Gangnam Severance Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria:<br><br> 1. Pathologically diagnosed with gastrointestinal cancers (stomach cancer,<br> pancreatobiliary cancer, colorectal cancer) prior to surgery.<br><br> 2. Clinically staged and anticipated to not receive adjuvant chemotherapy after<br> surgery.<br><br> 3. Eligible for complete surgical resection (R0 resection).<br><br> 4. ASA (American Society of Anesthesiologists) score of 3 or below.<br><br> 5. Intereseted in health functional foods.<br><br> 6. Not consumed probiotics or prebiotics for at least three months prior to study<br> enrollment.<br><br> 7. Willing to refrain from consuming additional probiotics or prebiotics during the<br> study period, apart from the provided red ginseng tablets.<br><br>Exclusion Criteria:<br><br> 1. Patients aged 80 years or older.<br><br> 2. Patients who received neoadjuvant therapy before surgery.<br><br> 3. Patients with underlying gastrointestinal disorders (e.g., inflammatory bowel<br> disease, ulcerative colitis, Crohn's disease, galactose intolerance, lactase<br> deficiency, glucose-galactose malabsorption, short bowel syndrome, other hereditary<br> gastrointestinal diseases, and autoimmune diseases).<br><br> 4. Patients unable to orally consume red ginseng tablets.<br><br> 5. Patients with a history of previous abdominal organ surgery, radiation therapy, or<br> chemotherapy.<br><br> 6. Patients with intestinal obstruction before surgery.<br><br> 7. Patients regularly taking probiotic or prebiotic supplements.<br><br> 8. Patients requiring formation of an ileostomy after surgery.<br><br> 9. Patients with uncontrolled diabetes that may affect gastrointestinal function.<br><br> 10. Patients with underlying conditions such as liver failure or renal failure.<br><br> 11. Patients allergic to red ginseng.<br><br> 12. Patients who received more than two weeks of antibiotic treatment during<br> hospitalization.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in microbiome composition based on the consumption or non-consumption of red ginseng following gastrointestinal cancer surgery.
- Secondary Outcome Measures
Name Time Method Improvement of gastrotintestinal symptoms;Improvement of bowel habits;Nutritional Indicators;Nutritional Indicators;Nutritional Indicator