Effect of Enteral Feeding's Macronutrient Composition on Inflammatory Mediators, Oxidative Stress and Outcomes in Intensive Care Unit Patients With Acute Respiratory Failure
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Acute Respiratory Failure
- Sponsor
- Zahra Vahdat Shariatpanahi
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- length of ventilation
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This study aimed to investigate the effect of enteral feeding's macronutrient composition on inflammatory mediators, oxidative stress and outcomes in Intensive Care Unit (ICU) patients with acute respiratory failure. In this double-blind randomized control trial, 42 patients of both sexes and diagnosed with acute respiratory failure in ICU that receive enteral feeding, will be randomly assigned to three groups of 14 each. First Intervention group; high-protein low-carbohydrate diet with high olive oil, the second intervention group; high-protein low-carbohydrate diet with high sunflower oil and control; high-protein kitchen formula. Intravenous levels of uric acid, high sensitive C-Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Total Antioxidant Capacity (TAC) measured at days 0 and 10. As well as, organ failure, duration of ventilation, length of ICU stay and mortality rates will be evaluated.
Investigators
Zahra Vahdat Shariatpanahi
Assistant professor
Shahid Beheshti University
Eligibility Criteria
Inclusion Criteria
- •enrolled in ICU
- •age older than 18 years old
- •need to be mechanically ventilation
- •have enteral feeding
- •no previous diabetes
- •no previous HIV infection
- •no previous nervous system
- •no previous liver failure
- •no previous nephrotic syndrome
- •not passed more than 48 hours from diagnose of acute respiratory failure
Exclusion Criteria
- •death at less than three days of enteral feeding administration
- •extubation at less than three days of enteral feeding administration
Outcomes
Primary Outcomes
length of ventilation
Time Frame: The number of days at least 3, to which days that patient extubated
The number of days from the patient intubation to his/her extubation
Secondary Outcomes
- Levels of Interleukin 6 (IL-6) in patient's vein blood(10 days)
- Levels of uric acid in patient's vein blood(10 days)
- Levels of high sensitive C-Reactive Protein (hs-CRP) in patient's vein blood(10 days)
- Levels of Total Antioxidant Capacity (TAC) in patient's vein blood(10 days)