Comparison between treatment of fungal infection of nail by laser and surgery
Not Applicable
- Conditions
- Health Condition 1: O- Medical and SurgicalHealth Condition 2: L608- Other nail disorders
- Registration Number
- CTRI/2021/05/033344
- Lead Sponsor
- GCS Medical College Hospital and Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Presence of fungus in nail clipping demonstrated by KOH/fungal culture
2) Dermoscopic findings suggestive of Onychomycosis
Exclusion Criteria
1) Individuals with photosensitive dermatoses
2) Individuals with contraindications to CO2 laser therapy like Isotretinoin use within the previous six months, history of keloid formation or hypertrophic scarring, ongoing ultraviolet exposure, prior radiation therapy to treatment area, collagen vascular disease
3) Individuals with deranged bleeding time, clotting time, PT, APTT
4) Individuals on antiplatelet therapy (Aspirin, clopidogrel, ticagrelor, etc)
5) Pregnant and lactating women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Clinical cure rate by nail examination and photographic evaluation <br/ ><br>2) Mycological cure rate by KOH microscopic examination <br/ ><br>3) Change in OSI (onychomycosis severity index score) <br/ ><br>Timepoint: At baseline and at the end of 6 months (for finger nails) and 9 months (for toe nails) <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1) To study adverse drug reactions due to topical and oral antifungal agents <br/ ><br>2) To study post operative complications after nail avulsion <br/ ><br>3) To study local complications after CO2 laser ablation <br/ ><br>Timepoint: Change in the above parameters at the end of 6 months in finger nails and 9 months in toe nails