Effects of physical and mental training on cognition and Alzheimer's disease biomarkers
Not Applicable
Completed
- Conditions
- Preventing or Delaying the onset of Cognitive declinePreventing or Delaying the onset of Alzheimer's diseaseMental Health - Other mental health disordersNeurological - Alzheimer's diseaseNeurological - Dementias
- Registration Number
- ACTRN12614000223639
- Lead Sponsor
- McCusker Alzheimer's Research Foundation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
1. Mini Mental State Examination (MMSE) greater than or equal to 24.
2. Personal physician fitness certificate stating that the participant is fit to take part in a home based physical exercise intervention program.
Exclusion Criteria
1. Diagnosis of any type of dementia including AD.
2. Uncontrolled medical condition–physical or mental that could lead to difficulty complying with the protocol including history of myocardial infarction, unstable or severe cardiovascular disease including angina or congestive heart failure, schizophrenia, bipolar disorder, anxiety neurosis or depression.
3. Arthritis causing any disability or restricted movements.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognition<br><br>1. Cambridge Cognitive Assessment - revised (CAMCOG-R). MMSE is a part of CAMCOG-R<br>2. Cambridge Contextual Reading Test (CCRT)<br>3. Rey auditory verbal learning test (RAVLT)<br>4. Controlled oral word association test (COWAT)<br>5. Cogstate computerized battery<br><br>Questionnaire - memory functioning questionnaire, short form 36 , international physical activity questionnaire, hospital anxiety and depression scale[Baseline, 8 weeks mid intervention and at 16 weeks on completion of the intervention<br>and at 52 weeks from baseline visit]
- Secondary Outcome Measures
Name Time Method