Brain Network Analysis in Hallucinations using Magnetoencephalography

Completed

Conditions: Hallucinations
hearing voices or seeing things
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10028037
10039628

Registration Number: NL-OMON42919

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

- Written informed consent for the study NL42959
- For the patient group: diagnosis of one of the following disorders: schizophrenia spectrum disorder, Parkinson*s disease, dementia with Lewy bodies, hearing loss
- For the patient control group: no hallucinations in the past two years, and lifetime no more than one week and one episode of hallucinations
- For healthy controls: no hallucinations in the past two years, and lifetime no more than one week and one episode of hallucinations, and no current psychiatric, neurological or perceptual disorder
- Mentally competent, as determined by researcher during informed consent meeting preceding study visit
- Written informed consent
- Age * 18;In case of the diagnostic group with hallucinations: patients have to have experienced one of these symptoms at least once within the last 30 days.

Exclusion Criteria

- Age < 18
- Participants that cannot read, speak or understand Dutch
- Mentally incompetent individuals who are not capable to provide informed consent, as determined by researcher during informed consent meeting preceding study visit
- For the patient control group: history of hallucinations in past two years and/or lifetime more than one week and one episode of hallucinations
- For the healthy controls: history of hallucinations in past two years and/or lifetime more than one week and one episode of hallucinations, and/or any current psychiatric, neurological or perceptual disorder
- Conditions that will cause excessive MEG artifacts (cardiac pacemaker / cardiac or neural defibrillators, metal fragments in the eyes, metal plates, pins or bolts in head, any magnetic implantation / implantations made from iron (ferrous products)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Detecting and characterizing functional network changes in different<br /><br>diagnoses underlying hallucinations. Questions that are addressed are: can<br /><br>changes in local and global connectivity be detected in brain networks of<br /><br>patients with and without hallucinations for the different diagnoses? Can brain<br /><br>regions be identified which are more affected than others and can regional<br /><br>differences in network change be related to region-specific properties of the<br /><br>network?<br /><br>2) Relating specific network changes to specific subtypes of hallucinations. If<br /><br>patterns of change in connectivity or regional changes in brain networks are<br /><br>found within or between different diagnoses, can a relationship with certain<br /><br>subtypes of hallucinations be established? </p><br>

Secondary Outcome Measures