nderstanding Hallucinations (part II) - fMRI & EEG

Recruiting

Conditions: Op het symptoom van hallucinaties in 6 verschillende diagnostische groepen: schizofrenie, Ziekte van Parkinson, Ziekte van Alzheimer, Lewy body dementie, patiënten die slechtziend zijn en patiënten die slechthorend zijn.
Hallucinations
illusory perceptional experience

Registration Number: NL-OMON45084

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 325

Inclusion Criteria

- Previous participation in the phenomenology/cognition study 13-059.
- Belong to one of the following diagnostic groups:
1.Patients with schizophrenia
2. Patients with Parkinson's disease
3. Patients with Lewy body dementia
4. Patients with Alzheimer's disease
5. Patients with hearing impairment
6.Patients with visual loss
- Written informed consent

Exclusion Criteria

- < 18 years of age
- Any contraindication for a 3Tesla MRI scan

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoints are differences between hallucinating and<br /><br>non-hallucinating participants and between hallucinating individuals of<br /><br>different subtypes in:<br /><br><br /><br>- resting state correlates as measured with fMRI, namely: connectivity within<br /><br>the DMN and connectivity of the DMN to sensory cortices and the<br /><br>hippocampal-amygdala complex.<br /><br>- EEG spectral analysis, synchronization likelihood, clustering index, path<br /><br>lengths and assortativity.<br /><br>- auditory and visual cortex synchronized burst activations.</p><br>

Secondary Outcome Measures