Onderzoek naar ‘dingen zien die er niet zijn’ bij psychotische aandoeningen (deel 2)
Recruiting
- Conditions
- visual hallucinations, psychotic disorders, fMRI
- Registration Number
- NL-OMON24629
- Lead Sponsor
- niversity Medical Center Groningen (UMCG)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 51
Inclusion Criteria
Patients must fulfill the following criteria:
1) meeting DSM-IV criteria for schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder NOS;
Exclusion Criteria
Exclusion criteria are:
1) other psychiatric disorders than above mentioned schizophrenia spectrum disorders that presumably affect our data:
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method fMRI study 1: cortical activation, reflected by the Blood-Oxygen-Level-Dependent (BOLD)-level, while an extended version of the Image Recognition Movies test is performed. In total, 50 pictures will be gradually pop out of white noise. During a movie, with random intervals, a central fixation square changes color. Participants are asked to push a button with their right middle finger on a response box, to keep attention constant. <br /><br>fMRI study 2: resting state scans: also cortical activation, reflected by the Blood-Oxygen-Level-Dependent (BOLD)-level. <br /><br>fMRI study 3: cortical activation, reflected by the Blood-Oxygen-Level-Dependent (BOLD)-level, during population receptive field mapping. <br />During this retinotopic mapping, participants are presented with a bar and wedges with a checkerboard pattern which moves across the screen.<br /><br>fMRI study 4: resting state scans while pushing buttons for VH: also cortical activation, reflected by the Blood-Oxygen-Level-Dependent (BOLD)-level.
- Secondary Outcome Measures
Name Time Method fMRI study 1: motor response for pushing buttons on recognition and when the central fixation square changes color<br /><br>fMRI study 3: motor responses, as during this test too, a central fixation dot changes color with random intervals. Participants are asked to push a button on a response box, to keep attention constant.<br /><br>fMRI study 4: motor responses, as during this scan patients push a button when they start experiencing VH, and push an other button when the VH stops.