Evaluation of "Beauty Drink" on Regulation of Blood Pressure Effect by Clinical Trial

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Dietary Supplement: Beauty Drink; Dietary Supplement: Placebo

• Registration Number: NCT03663127
• Lead Sponsor: Chung Shan Medical University

Brief Summary

This report assesses the effect of supplementation with gamma-aminobutyric acid on blood pressure among people with mild hypertension. Overall, "Beauty Drink" consumption for 8 weeks could successfully reduce mean diastolic and systolic BP through the suppression of ACE linked to downstream suppression of angiotensin II formation, which further decreases the sympathetic outflow leads to hypertension.

Detailed Description

This report assesses the effect of supplementation with gamma-aminobutyric acid on blood pressure among people with mild hypertension. Fifty subjects with systolic blood pressure (SBP) between 120 and 159 mm Hg and/or diastolic blood pressure (DBP) between 80 and 99 mm Hg were randomized to ingest 2 bottles of "Beauty Drink" or placebo per day for 8 weeks of a stage. In addition, anthropometric measurements (blood pressure, body weight, body fat) and blood biochemical markers including fasting blood glucose (FBG), albumin, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, creatinine (Cr), blood urea nitrogen (BUN), AST, ALT were examined every four weeks.

Study Timeline

• Study Start: 2018-07-26
• Study First Submitted: 2018-09-06
• Study First Submitted QC: 2018-09-06
• Study First Posted: 2018-09-10
• Primary Completion: 2018-12-21
• Study Completion: 2019-06-30
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-24
• Last Update Posted: 2021-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Eligible subjects were untreated hypertensive men or women aged between 20 and 70 years old with SBP between 120 and 159 mmHg and/or DBP between 80 and 99 mmHg as measured in a sitting position

Exclusion Criteria

• Subjects were excluded if they had a history of major cardiovascular disease or severe liver dysfunction; Diastolic blood pressure ≥ 100 mmHg or Systolic blood pressure ≥ 160 mmHg;
• Alcoholic;
• US-controlled diabetics;
• Stoke in past one year;
• Mental diseases or melancholia;
• Pregnancy or breast-feeding a child;
• Renal dysfunction;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Beauty Drink	Beauty Drink	Subjects receive two bottles "Beauty Drink" per day for 8 weeks of a stage.
Placebo	Placebo	Subjects receive two bottles placebo per day for 8 weeks of a stage.

Primary Outcome Measures

Name	Time	Method
The changes of blood pressure of the subjects (SBP and DBP)	8 weeks	values change of systolic and diastolic BPs between before to after 8 weeks

Trial Locations

Locations (1)

Chung Shan Medical University; 🇨🇳 Taichung, Taiwan