Sensory axons in multifocal motor neuropathy (MMN)
- Conditions
- multifocal motor neuropathy (MMN). This term is familiar to all MMN patients.10034606
- Registration Number
- NL-OMON42685
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
1. Diagnosis of MMN according to internationally accepted criteria of the European Federation of Neurological Societies and Peripheral Nerve Society (EFNS/PNS criteria).
2. One median nerve (left or right) with any of the follwing abnormalities in the motor nerve conduction studies:
a) conduction block in motor axons in the forearm segment, defined as segmental reduction of compound muscle action potential (CMAP) area of at least 30%;
b) signs of demyelination: conduction velocity decrease up to 38 m/s or less and/or DML 5.3 ms or more and/or increase CMAP duration in the forearm of at least 30%;
c) motor axon loss defined as decreased CMAP amplitude of 3 mV or less;
3. Age range 18-99 years old.
1. Other causes for neuropathy than MMN, including carpal tunnel syndrome (CTS).
2. Use of medication affecting ion-channels in nerves.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Excitability-variables of motor and sensory axons of the median nerve at the<br /><br>wrist.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>