Multifocal motor neuropathy: a study on immunological mechanisms and natural history

Completed

Conditions: disease of motor nerves
inflammatory demyelinating peripheral motor neuropathy
10012303

Registration Number: NL-OMON44983

Lead Sponsor: niversitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 320

Inclusion Criteria

Patients are subjects who fullfil the diagnostic consensus criteria for MMN (see protocol, page 40)
Controls are people who visit the neuromuscular outpatient clinic for diseases other than MMN.
All subjects are older than 18 year, are not mentally incapacitated and fully understand the given information for the study

Exclusion Criteria

An MMN patient who meets any of the following criteria will be excluded from participation in this study:
- Doubts about the diagnosis MMN
- Relevant concomitant illnesses (i.e. haematological or immunological diseases) that may interfere with any part of the study
A control will be excluded when any of the following criteria is met:
- having MMN as a diagnosis in the history
- under 18 years old.
- not capable of understanding the given information or giving consent.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Natural history:<br /><br>Clinical disease course is determined by questionnaires and a neurological<br /><br>examination taken in 2007 and in the current study. Special (clinical) features<br /><br>is looked for in patients that have poor prognosis.<br /><br>Quality of life scores compared to the standardized Dutch scores.<br /><br><br /><br>Immunological part:<br /><br>Anti-GM1 IgM titers and HLA haplotyping in MMN and controles<br /><br>-FcuR status on (subsets of) leukocytes is compared with controls.<br /><br>- Bacterial cultures that can express GM1 (like) epitopes is compared with<br /><br>controls.</p><br>

Secondary Outcome Measures