Prevention of Intrathecal Morphine Induced Pruritus: Comparison of Ondansetron and Palonosetron
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Incidence of pruritus
研究概览
简要总结
Intrathecal administration of morphine is often used for control of postoperative pain. However, pruritus is one of the most common side effects of intrathecal morphine . Specific serotonin receptor antagonists could be an effective prophylactic treatment of neuraxial opioid-induced pruritus. It was reported that palonosetron is more effective than ondansetron for prevention of postoperative nausea and vomiting. Therefore, the investigators evaluated the efficacy of prophylactic administration of ondansetron and palonosetron for the prevention of intrathecal morphine-induced pruritus.
详细描述
Intrathecal administration of morphine is often used for relief of postoperative pain. However, pruritus is one of the most common side effects associated with intrathecal morphine. Specific serotonin receptor antagonists such as ondansetron could be an effective prophylactic treatment of neuraxial opioid-induced pruritus. It was reported that palonosetron is more effective than ondansetron for prevention of postoperative nausea and vomiting. Therefore, the investigators evaluated the efficacy of prophylactic administration of ondansetron and palonosetron for the prevention of intrathecal morphine-induced pruritus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •19-70 years,
- •American Society of Anesthesiology physical status 1 and 2
- •Scheduled for elective urologic surgery under spinal anesthesia.
排除标准
- •Patients with cardiac and psychological problems.
- •Patients who take sedatives or narcotics.
- •Patient who have allergy to study drugs.
研究组 & 干预措施
ondansetron
Intravenous administration of ondansetron 4mg 15 minutes before spinal anesthesia
干预措施: Ondansetron (Drug)
palonosetron
Intravenous administration of palonosetron 0.075mg 15 minutes before spinal anesthesia
干预措施: Palonosetron (Drug)
结局指标
主要结局
Incidence of pruritus
时间窗: 24 hours after spinal anesthesia
record of the incidence of pruritus after spinal anesthsia
次要结局
未报告次要终点
研究者
Younghoon Jeon
Associate professor
Kyungpook National University Hospital