Pruritus After Intrathecal Morphine in Cesarean Section: Incidence, Severity and Its Relation to Serum Serotonin Level
Overview
- Phase
- Phase 4
- Intervention
- Morphine 100 μg
- Conditions
- Pruritus
- Sponsor
- Assiut University
- Enrollment
- 40
- Primary Endpoint
- Pruritus
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Pruritus is the commonest side effect of intrathecal morphine especially in parturient, but the exact mechanism of pruritus is not clear. Many mechanisms have been suggested. Among these mechanisms is the activation of the 5-HT3 receptors by the intrathecally injected morphine.
Detailed Description
Forty parturients underwent elective cesarean section under spinal anesthesia were divided into two groups of 20 each in this prospective randomized study. Group I received 100 µg of intrathecal morphine (ITM) mixed with 12 mg of 0.5% heavy bupivacaine (M100) while group II received 200 µg of ITM mixed with 12 mg of 0.5% heavy bupivacaine (M200). Two blood samples were taken from each patient for serotonin estimation, preoperatively and 4 hrs later. Postoperatively all patients were assessed for pruritus (incidence \& severity), visual analog scale (VAS), first request of analgesia, and total analgesic dose required within 24 hrs.
Investigators
Mohamed galal aly
Assistant professor
Assiut University
Eligibility Criteria
Inclusion Criteria
- •ASA I - II term pregnant patients scheduled for elective cesarean section
Exclusion Criteria
- •patients with a known allergy to the study drugs
- •significant cardiac, respiratory, renal, neurological, or hepatic disease; -coagulation disorders
- •BMI \> 30 kg/m2
- •any itchy skin diseases.
Arms & Interventions
Group I
intrathecal injection of 100 μg morphine
Intervention: Morphine 100 μg
Group II
iIntrathecal injection of 200 μg morphine
Intervention: Morphine 200 μg
Outcomes
Primary Outcomes
Pruritus
Time Frame: 24 hours postoperative
severity
Secondary Outcomes
- serotonin(4 hours postoperative)