Effect of Captopril and Carvedilol in Hypertension Urgency.

Phase 3

Recruiting

Conditions: Hypertension.
Essential (primary) hypertension

Registration Number: IRCT20200723048182N1

Lead Sponsor: Islamic Azad University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

Refer to the hospital emergency department with symptoms of blood pressure equal to or greater than 160/90 mmHg in patients with hypertension or blood pressure equal to or greater than 180/110 mmHg in patients with new onset of the disease in the age range of 18 to 65 years.
Obtaining written consent from patients.
Complete the file and information contained in the questionnaire form.

Exclusion Criteria

Failure to obtain written consent from patients
Defects in the file and information contained in the questionnaire form
Patients with acute chest pain
Bradycardia
History of heart block or sick sinus syndrome
Irreversible heart failure
Pulmonary edema
Aortic dissection
Patients who need intravenous drugs to control blood pressure or require high doses of ACEIs and ARBs (captopril> 50 mg / d, enalapril> 10 mg / d, lisinopril> 5 mg / d, losartan> 50 mg / d, valsartan > 80 mg / d).
Loss of consciousness
Seizure
Cerebrovascular accidents (ischemia or bleeding)
Acute or chronic renal failure
Previous history of pheochromocytoma
History of bilateral renal artery stenosis
Pregnancy
Hypertension after surgery
Diastolic blood pressure above 120
History of allergies to captopril and carvedilol and allergies to penicillin and sulfonamides.
Asthma or other bronchospasm diseases
Existence of cardiogenic shock
Severe liver failure
Papillary edema
Anuria

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Systolic blood pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: With a hand pressure gauge and with a scale of millimeters of mercury.;Diastolic blood pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: With a hand pressure gauge and with a scale of millimeters of mercury.;Mean blood pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: After measuring systolic and diastolic blood pressure its measured with the sum of twice the diastolic blood pressure and the systolic blood pressure divided by three ((2DBP + SBP)/3) will be calculated.;Heart rate. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: By counting the number of radial pulses.

Secondary Outcome Measures

Name	Time	Method
Satisfaction rate. Timepoint: At intervals and ends of measurements. Method of measurement: questionnaire.;Drug side effects. Timepoint: At intervals and ends of measurements. Method of measurement: questionnaire.