Hydrodissection in Carpal Tunnel Syndrome
- Conditions
- Carpal Tunnel Syndrome
- Interventions
- Procedure: Ultrasound guided median nerve hydrodissection injection with Hyaluronic acidProcedure: Ultrasound guided median nerve hydrodissection injection with Dextrose water
- Registration Number
- NCT06188390
- Brief Summary
Compare the efficacy on carpal tunnel syndrome (CTS) treatment between hydrodissection with hyaluronic acid (HA) vs 5% dextrose
- Detailed Description
Compare the efficacy on carpal tunnel syndrome treatment between hydrodissection with hyaluronic acid vs 5% dextrose through ultrasonographic evaluation.; 2) Evaluate the association of median nerve gliding results between using duplex Doppler ultrasound and B mode video with cross-correlation algorithm.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- 20-80 years old patients with carpal tunnel syndrome
- pregnancy, Diabetes, hypothyroidism, uremia, rheumatoid arthritis, coagulopathy, cervical radiculopathy and patients who has ever received surgery for carpal tunnel syndrome or wrist fracture
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Hyaluronic acid group Ultrasound guided median nerve hydrodissection injection with Hyaluronic acid Hyaluronic acidwas injected under ultrasound guidance around wrist median nerve Dextrose group Ultrasound guided median nerve hydrodissection injection with Dextrose water Dextrose was injected under ultrasound guidance around wrist median nerve
- Primary Outcome Measures
Name Time Method Boston CTS (carpal tunnel syndrome) questionnaire before injection , 2 weeks, 3 months and 6 months after injection. The Boston CTS questionnaire is self-administered and is composed of two parts: the symptom severity scale (11 questions) and the functional status scale (8 questions).A final score is calculated for each scale (the sum of the individual scores divided by the number of items) and ranges from 1 to 5, with a higher score indicating a more severe handicap.
- Secondary Outcome Measures
Name Time Method Ultrasonography (B mode) of median nerve before injection , 2 weeks, 3 months and 6 months after injection. Transverse ultrasonograms were obtained at the level of pisiform bone. Using electronic calipers, the CSA of the median nerve was measured by tracing the margin of the inner border of the perineural hyperechogenic rim that surrounded the hypoechoic median nerve , unit : mm2
Nerve conduction study (NCS) of median nerve before injection , 3 months and 6 months after injection. Distal motor latencies of the median and ulnar nerve were respectively measured by placing a stimulating electrode at the wrist and a recording electrode 8 cm away from the stimulating electrode on the abductor pollicis brevis muscle and the adductor digiti minimi muscle. For sensory NCSs of the median and ulnar nerves, a standard distance of 14 cm was maintained between the stimulating electrode at the wrist and the recording electrodes at the ring finger on radial and ulnar sides
Ultrasonography (duplex Doppler) of median nerve before injection , 2 weeks, 3 months and 6 months after injection. An ultrasonography probe was placed longitudinally at the level of the lunate-capitate intercarpal joint to obtain a clear image of the median nerve. Longitudinal gliding excursions of the median nerve and flexor tendon were recorded using Doppler ultrasonography. The saved images were transferred to a personal coputer and analyzed by a researcher who was unaware of the individual and group identity of each image
Trial Locations
- Locations (1)
Department of Physical Medicine and Rehabilitation, Taipei Tzu chi Hospital, Buddhist Tzu chi Medical Foundation
🇨🇳New Taipei City, Taiwan