Mechanobiological characterisation of the herniated intervertebral disc before and after light activated riboflavin collagen cross-linking
Recruiting
- Conditions
- M51Other intervertebral disc disorders
- Registration Number
- DRKS00028752
- Lead Sponsor
- Klinikum der Universität Freiburg, Klinik für Neurochirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
Patients with IVD herniations/advanced degeneration requiring surgical resection.
Exclusion Criteria
Patients unable to consent.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method • Spatial spectroscopic characterization of IVDs and correlation with clinical, radiologic and IVD-proteomic patient data<br>• Extracellular matrix (ECM) characterization of IVDs prior and after LARC treatment with optical coherence tomography (OCT)<br>• ECM characterization of IVDs prior and after LARC treatment with atomic force microscopy (ATM)<br>• Biomechanical evaluation of IVDs prior and after LARC treatment.
- Secondary Outcome Measures
Name Time Method • Spatiotemporal proteomic characterization of IVDs.<br>• Evaluation of inflammation markers and correlation with clinical and radiologic patient data.