JPRN-UMIN000003783
Completed
Phase 2
A multicenter randomized phase II/III trial of preoperative versus postoperative chemotherapy with XELOX plus bevacizumab in patients with resectable colorectal liver metastasis. - Randomized phase II/III trial of preoperative versus postoperative chemotherapy in patients with resectable colorectal liver metastasis. (HiSCO-01)
Hiroshima Surgical study group of Clinical Oncology0 sites81 target enrollmentJuly 1, 2010
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Resectable liver metastasis from colorectal cancer
- Sponsor
- Hiroshima Surgical study group of Clinical Oncology
- Enrollment
- 81
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1\) Multiple cancer patients 2\) Pregnant or lactating woman 3\) Steroid administration 4\) Patients must use flucytosine, phenytoin or warfarin potassium 5\) Uncontrollable hypertension or diabetes mellitus 6\) Diarrhea or peripheral neuropathy greater than grade 1 7\) Portal vein embolization 8\) Clinically significant pulmonary disease, coagulopathy or thrombosis. 9\) Clinically significant gastrointestinal bleeding, obstruction or ulcer. 10\) Clinically significant abdominal, pleural or pericardial effusion. 11\) Presence of psychological or central nervous system disorder. 12\) Major abdominal or thoracic surgery within 4 weeks. 13\) Presence of non\-healing bone fracture 14\) Hepatitis B virus infection
Outcomes
Primary Outcomes
Not specified
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