Combination of Etoricoxib and Low Pressure Pneumoperitoneum versus Standard Treatment for the Management of Pain after Laparoscopic Cholecystectomy: A Double-Blind Randomized Controlled Trial
Phase 4
Completed
- Conditions
- Patients with gallstone who underwent laparoscopic cholecystectomyEtoricoxibLow pressureStandard pressurePneumoperitoneumLaparoscopic cholecystectomy
- Registration Number
- TCTR20140213001
- Lead Sponsor
- Royal College of Surgeons of Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
ASA 1-2 patients age 18-75 years requiring elective laparoscopic cholecystectomy were eligible for enrollment in the study.
Exclusion Criteria
1) Acute preoperative pain other than biliary colic
2) Require chronic pain treatment
3) Advanced renal disease (creatinine clearance < 30 ml/min)
4) Heart failure or fluid retention
5) Using preoperative NSAIDs or opioids within 24 hours of the schedule operation
6) A known hypersensitivity to NSAIDs
7) Pregnant patients
8) Morbid obesity (BMI > 35 kg/m2)
9) Contraindication for etoricoxib such as ischemic heart disease, severe hepatic impairment (Child-Pugh score > 9), lactating patient
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain score at rest and on movement At 1, 2 hours postoperatively, and then every 4 hours until discharge Numeric rating scale (0-10)
- Secondary Outcome Measures
Name Time Method analgesic drug use At 1, 2 hours postoperatively, and then every 4 hours until discharge Record rescuse drug