Effect of low dose steroids on blood glucose and risk of heart disease

• Conditions: Insulin sensitivity; cardiovascular risk; energy metabolism; inflammatory arthritis; Cardiovascular - Coronary heart disease; Metabolic and Endocrine - Diabetes; Inflammatory and Immune System - Rheumatoid arthritis

• Registration Number: ACTRN12612000540819
• Lead Sponsor: Morton Burt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Group 1 : Has inflammatory rhematologic disease
No prednisolone for >6 months
Age >30years
Group 2 : Has inflammatory rhematologic disease
Taking prednisolone 4 to 10 mg/day for >6months
Age >30years

Exclusion Criteria

Taking oral hypoglycemic agents, insulin or beta blockers
Atrial fibrillation
Inability to provide written informed consent
History of claustrophobia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in postprandial reduction in Augmentation index<br> ( assessed by pulse wave analysis form radial artery using sphygmocor device) with glucocorticoids.[Longitudinal study (acute study):baseline and after seven day course of prednisolone (dose= mean dose of group2).<br>Cross-sectional study: baseline.]