ACTRN12623000653662尚未招募Unknown
A registry study to prospectively describe the proportion of advanced cancer patients being treated with immunotherapy who remain progression free at 6 months after local treatment of up to five sites of oligoprogressive disease
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 入组人数
- 33
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Patients with histologically proven advanced cancer receiving immunotherapy. Advanced cancer will include any unresectable locally advance or metastatic cancer, primary tumour agnostic. Accepted tumour types will include melanoma, lung cancer, renal cell carcinoma, urothelial cancer, head and neck cancers, and deficient MMR cancer of any primary.
- •2. On systemic immunotherapy, either alone or in combination the chemotherapy or another systemic treatment.
- •3. Must have evidence of extracranial metastatic disease with or without intracranial metastases.
- •4. Clinically or radiologically stable or responding disease to immunotherapy for a period of at least 12 weeks prior to study entry with ongoing clinical benefit as deemed by treating clinician.
- •5. Evidence of isolated progression in 1-5 lesions amenable to local treatment.
- •6. Planned local treatment to sites of oligoprogression which can include surgery and/or radiotherapy.
- •7. Baseline staging either via CT or PET/CT needs to be obtained within 4 weeks of commencement of local therapy. An MRI brain will be required for local therapy of oligoprogressive brain metastases
排除标准
- •1. Pregnancy or lactation at the time of study entry
- •2. Primary brain tumours
- •3. Evidence of leptomeningeal disease
- •4. Evidence of malignant spinal cord compression
- •5. Contraindication to radiotherapy and/or surgery as local therapy
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