A CLINICAL TRIAL TO ASSESS THE ROLE OF CONCURRENT VALPROATE WITH CHEMORADIATION IN HIGH GRADE GLIOMA
Phase 2
Completed
- Conditions
- Health Condition 1: null- HIGH GRADE GLIOMA (ANAPLASTIC ASTROCYTOMA GRADE III, GLIOBLASTOMA GRADE IV)Health Condition 2: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2018/08/015512
- Lead Sponsor
- PGIMER CHANDIGARH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1. Histologically confirmed cases of high grade gliomas (Anaplastic Astrocytoma Grade III and Glioblastoma Grade IV)
2. KPS >60
3. Life expectancy >8 weeks
4. Adequate renal, hepatic andhematological function
5. Taking any anti epileptic except Valpraote as seizure prophylaxis
6. Willing to participate in study
Exclusion Criteria
1. Previous history of use of Valproate or hypersensitivity to Valproate
2. Pregnancy
3. History of acute or chronic liver disease
4. Any history of comorbidities (Diabetes, Hypertension etc) not controlled on medication
5. Patients having second malignancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method