Does sexual inequality start in utero with sex differences in the placental transcriptome

Not Applicable

• Conditions: Gene expression in placentas collected from healthy fetuses; Reproductive Health and Childbirth - Normal pregnancy

• Registration Number: ACTRN12612000999831
• Lead Sponsor: niversity of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-09-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Caucasian women pregnant with a singleton or twins who will deliver by elective cesarean. Non-smokers BMI 20-40
Fathers of the pregnancy (where possible) will asked to supply a saliva sample for genome-wide SNP genotyping.

Exclusion Criteria

Severe complication of pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification and expression level of all genes in male and female placentas. We will sequence RNA molecules using the Illumina Hi-Seq and Microarray platforms to generate the data and test the differences between the sexes using established and custom designed bioinformatics pipleines.[At the time of delivery]

Secondary Outcome Measures

Name	Time	Method
o Secondary outcome[NA]