A prospective observational study to assess the predictive value of simple blood count based marker versus advanced cytokine biomarker for outcomes in off-pump coronary artery bypass surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Acute Kidney Injury (AKI) in off-pump coronary artery bypass grafting
研究概览
简要总结
Keeping in mind the inflammatory background of coronary artery disease, currently various inflammatory markers are being used to predict the outcomes in patients of off pump cardiac surgery like IL-1, IL-6, TNF- alpha etc. Since these tests are very costly and there is growing evidence presenting the role of whole blood count inflammatory markers in prediction of morbidity and mortality in coronary artery diseases we are planning this observational study to assess the predictive value of simple blood count based markers versus advanced cytokine biomarkers for outcomes in off-pump coronary artery bypass surgery.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing elective off pump Coronary Artery Bypass Grafting.
- •Isolated CABG as per ESC/EACTS 2018 guidelines Age more than 18 years Either sex.
排除标准
- •Patient refusal Patient undergoing repeat surgical procedures.
- •Patients receiving steroid, NSAIDS, immunomodulatory therapy Patients having chronic HTN, chronic renal failure, serum ALT or AST level of twice the baseline value, active infection (preoperative total leukocyte count of more than 11.000/mm3) Those having history of recent CVA or MI (within 1 month) Severe LV dysfunction (LVEF less than 30%) Pre existing AF or utilizing antiarrhythmic therapy Preexisting neurological disease Patients of oncologic diseases.
结局指标
主要结局
Acute Kidney Injury (AKI) in off-pump coronary artery bypass grafting
时间窗: 48 HOURS
次要结局
- 1- Atrial Fibrillation ( AF), and 3 Point Major Adverse Cardiovascular(Events (3P-MACE) which includes coronary heart disease death, fatal or)
研究者
Dr Sarah Iqbal
Jawaharlal Nehru Medical College, Aligarh Muslim University