Efficacy of metoprolol versus clonidine in acute stroke blood pressure and heart rate variability.
- Conditions
- Health Condition 1: G988- Other disorders of nervous system
- Registration Number
- CTRI/2024/01/061406
- Lead Sponsor
- AIIMS Bhubaneswar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients of age >18yrs.
2. Ischemic & hemorrhagic
3. NIHSS SCORE – 5-20 at the time of admission ,ensuring that stroke is neither mild nor
devastating
4. GCS > 5 at admission
5. Only first episode stroke patients to be included.
1. Cardioembolic stroke
2. Disability prior to present stroke (prestroke MRS should be < 2)
3. Posterior circulation strokes
4. Undergoing Decompressive craniectomy
5. Venous strokes to be excluded
6. Any contraindications to drugs involved(contraindications to beta blocker –
asthma,chronic obstructive pulmonary disease,previous intolerance to beta blockers)
7. Another clinical need for beta blockers which cannot be met with other drugs.
8. Patients with cardiac rhythm disturbances
9. Pregnancy and lactation
10. Chronic Kidney Disease
11. Hepatic insufficiency
12. Malignancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in Blood Pressure and Pulse Rate variability after 7 days of maximum dose <br/ ><br>titration.Timepoint: Reduction in Blood Pressure and Pulse Rate variability after 7 days of maximum dose <br/ ><br>titration.
- Secondary Outcome Measures
Name Time Method 1.A secondary outcome will be Modified Rankin Scale reduction at 1 and 3 months in metoprolol versus clonidine group. <br/ ><br>2.A secondary outcome will be blood pressure and pulse rate varibitlity in hemorrhagic versus ischemic stroke. <br/ ><br>3.A secondary outcome will be blood pressure and pulse rate variability in right sided versus left sided stroke. <br/ ><br>Timepoint: 1 and 3 months