Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
Phase 2
- Conditions
- CancerPainPalliative Care
- Interventions
- Registration Number
- NCT00525967
- Lead Sponsor
- Faculdade de Medicina do ABC
- Brief Summary
The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.
- Detailed Description
Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is the most commonly used, methadone has some advantages such as higher potency, lower cost and longer administration intervals. To minimize the time necessary to achieve the equianalgesic effect after a switching from morphine to methadone, acetaminophen was added in the treatment.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Clinical diagnosis of cancer pain
- Regular use of oral Morphine
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Exclusion Criteria
- Use of Acetaminophen in the last 48 hours
- Renal or Hepatic failure
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Methadone plus Acetaminophen or Placebo Methadone plus Acetaminophen 1 Methadone plus Acetaminophen or Placebo Methadone plus Placebo
- Primary Outcome Measures
Name Time Method Pain intensity and time to equianalgesic effect within the first 7 days after switching
- Secondary Outcome Measures
Name Time Method Degree of nausea, vomiting, obstipation, xerostomia and drowsiness within the first 7 days of switching
Trial Locations
- Locations (1)
Disciplina de Oncologia, Faculdade de Medicina do ABC
🇧🇷Santo André, São Paulo, Brazil