Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study
试验速览
- 阶段
- 2 期
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Pain intensity and time to equianalgesic effect
研究概览
简要总结
The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.
详细描述
Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is the most commonly used, methadone has some advantages such as higher potency, lower cost and longer administration intervals. To minimize the time necessary to achieve the equianalgesic effect after a switching from morphine to methadone, acetaminophen was added in the treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of cancer pain
- •Regular use of oral Morphine
排除标准
- •Use of Acetaminophen in the last 48 hours
- •Renal or Hepatic failure
研究组 & 干预措施
1
Methadone plus Placebo
干预措施: Methadone plus Acetaminophen or Placebo (Drug)
2
Methadone plus Acetaminophen
干预措施: Methadone plus Acetaminophen or Placebo (Drug)
结局指标
主要结局
Pain intensity and time to equianalgesic effect
时间窗: within the first 7 days after switching
次要结局
- Degree of nausea, vomiting, obstipation, xerostomia and drowsiness(within the first 7 days of switching)