Delayed Response to Antipsychotic Medication in Psychosis
- Conditions
- Health Condition 1: null- Non Affective Psychosis
- Registration Number
- CTRI/2017/11/010391
- Lead Sponsor
- Goverment Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Patient should meet the following psychopathology severity criteria at the time of inclusion into the study
1.total score extracted from Positive and Negative Syndrome Scale should be atleast 45
2. A score of atleast 4 [moderate] on at least 2 of following BPRS items: conceptual disorganization, suspiciousness, hallucinatory behavior and unusual thought content
3.Patient who are either drug naïve or who had relapsed in preceding 2 weeks requiring change in medications.
1.Patient with history of inadequate response to risperidone or olanzapine in the past.
2.Patient with history of allergic reaction to risperidone or olanzpine
3.History of use of risperidone or olanzapine with in past 30 days before the study enrolment.
4.Acute, serious or unstable co-morbid medical condition
5.Schizo-affective disorder
6.Active substance dependence except nicotine and caffeine
7.Pregnant and lactating women
8.Treatment resistant schizophrenia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Identify the early responder and non responder <br/ ><br>2.the response rate amongst the early non-responders after either continuing on the same antipsychotic or being switched over to another atypical antipsychoticTimepoint: 1t week,2nd week,4th week,6th week,8th week.
- Secondary Outcome Measures
Name Time Method 20% Reduction in the illness severity on PANSS.Timepoint: 2nd week