ACTRN12624000146594
Recruiting
未知
Assessment of regional lung ventilation via X-ray velocimetry (XV) imaging following thecommencement of ETI (elexacaftor/tezacaftor/ivacaftor) treatment in children with cystic fibrosis
Women's and Children's Hospital0 sites20 target enrollmentFebruary 15, 2024
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- cystic fibrosis
- Sponsor
- Women's and Children's Hospital
- Enrollment
- 20
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Children with cystic fibrosis aged 5\-18 years planning to start ETI (elexacaftor/tezacaftor/ivacaftor) treatment in the next 3 months
- •\- must have a clinically indicated CT chest completed prior to screening or scheduled within the next 4 weeks
- •\- must be willing to attempt all lung function testing and complete one of: spirometry, lung volumes, diffusing capacity, multiple breath washout
Exclusion Criteria
- •\- pulmonary exacerbation within 4 weeks of planned screening visit
- •\- currently receiving mechanical ventilation, intensive or other critical care
- •\- contraindication to ionising radiation
- •\- inability to remain still for periods of 30 seconds for each of the 5 XV image acquisitions during an XV scan
- •\- use of ETI (elexacaftor/tezacaftor/ivacaftor) before Screening procedures are complete
Outcomes
Primary Outcomes
Not specified
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