The effect of vitamin k1 in diabetic patient treatment
Phase 2
- Conditions
- prediabetes.Abnormal glucose tolerance test
- Registration Number
- IRCT2013120915724N1
- Lead Sponsor
- Vice Chancellor For Research Of Ahvaz Jundishapur University Of Medical Science, Ahvaz Jundishapur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 84
Inclusion Criteria
Willingness to participate in the study and sign the Written informed consent; Age between 22 to 45 years old; BMI=25-29.9 kg/m2; 100 =FBS=126 or 140 =2hpp=200 mg/dL
Exclusion criteria: Heart, Kidney, liver and Rheumatoid diseases; Osteoporosis; Hyperthyroidism and Thyroid dysfunction; Pregnancy; Lactation; Menopause; Intake of insulin and glucose and lipid-lowering Agents; Warfarin; Corticosteroids; drugs to treat osteoporosis; Vitamin and Mineral supplements during past 6 months.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum carboxylated osteocalcin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum carboxylated osteocalcin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum total osteocalcin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum Hb A1C. Timepoint: Baseline and after 4 weeks. Method of measurement: HPLC assay.;Total energy and nutrient intaake. Timepoint: Baseline, middle and 4th weeks. Method of measurement: 24 hour recall.
- Secondary Outcome Measures
Name Time Method Fasting and 2 hour serum insulin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Fasting and 2 hour serum glucose. Timepoint: Baseline and after 4 weeks. Method of measurement: calorimetric assay.;HOMA-IR. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;HOMA-%B. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;ISI. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;Serum adiponectin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum leptin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;BMI. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;Waist to hip ratio. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;Bady fat. Timepoint: Baseline and after 4 weeks. Method of measurement: OMRON.