The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness

• Conditions: Propofol
• Interventions: Drug: Propofol

• Registration Number: NCT03762538
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

The aim of this study is to determine whether ALDH2 gene polymorphisms (G/G, G/A A/A) have effect on the potency of propofol.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2018-01
• Study First Submitted: 2018-11-27
• Study First Submitted QC: 2018-11-30
• Last Update Submitted: 2018-11-30
• Study First Posted: 2018-12-03
• Last Update Posted: 2018-12-03
• Study Start: 2019-02-01
• Primary Completion: 2019-06-30
• Study Completion: 2019-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

• ASA II

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Exclusion Criteria

• ASA III-IV
• OSAS
• hepatic and renal insufficiency

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
G/A A/A group	Propofol	Patients who are determined to be G/A or A/A genotypes.
G/G group	Propofol	Patients who are determined to be G/G genotype.

Primary Outcome Measures

Name	Time	Method
Effect-site concentration	immediately after patient lose his/her consciousness	patient's effect-site concentration when he/she loss consciousness