NCT00884494已完成1 期
Role of Ghrelin in the Improvement of Insulin Resistance After Roux-en-Y Gastric Bypass Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Evaluate the effect of ghrelin on insulin resistance in obese subject, as well as subjects in the immediate post-RYGB period.
研究概览
简要总结
Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin. The purpose of this study is to determine if the decline in ghrelin levels after weight loss surgery contributes to the improvement of insulin sensitivity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Prior bariatric surgery
- •Serum creatinine > 1.5 mg/dl
- •Hepatic enzyme elevations > 2x upper limits of normal
- •Current use of warfarin or clopidogrel
- •Intercurrent infections
- •Females with positive pregnancy test
- •Abnormal ECG
研究组 & 干预措施
Roux-en-Y gastric bypass
Experimental
干预措施: Ghrelin infusion to assess effects on insulin sensitivity (Drug)
Lean
Experimental
干预措施: Ghrelin infusion to assess effects on insulin sensitivity (Drug)
结局指标
主要结局
Evaluate the effect of ghrelin on insulin resistance in obese subject, as well as subjects in the immediate post-RYGB period.
时间窗: 1 year
次要结局
未报告次要终点
研究者
Robyn Tamboli
Research Associate Professor
Vanderbilt University Medical Center
研究点 (1)
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