NCT00512525已完成1 期
Intravenous Ghrelin Infusion Decreases Insulin Sensitivity in Healthy Young Men
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 8
- 主要终点
- Insulin sensitivity
研究概览
简要总结
Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.
详细描述
The current study is initiated in order to assess the impact of acute ghrelin administration on insulin resistance measured by a hyperinsulinemic euglycemic clamp. Second, as free fatty acid is the predominant substrate during fasting, we aim to asses the effects of ghrelin on local and systemic lipolysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Health Services Research
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy men, age >= 18 yr age < 50 yr, body mass index < 27.5 kg/m2above or equal to 18 yr
排除标准
- •any disease, use of prescribed medication, age < 18 yr or >= 50 yr
研究组 & 干预措施
2
Placebo Comparator
干预措施: Ghrelin and saline (as placebo) (Drug)
结局指标
主要结局
Insulin sensitivity
时间窗: End of clamp period
次要结局
- Effects on lipolysis(End of basal and end og clamp period)
研究者
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