A CLINICAL STUDY ON EFFECTIVENESS OF ATASI TAILA NASYA (LINUMUSITATISSIMUM Linn) IN THE MANAGEMENT OF VISHADA (MILD TOMODERATE DEPRESSION)

Phase 2

Not yet recruiting

• Conditions: Major depressive disorder, singleepisode, moderate,

• Registration Number: CTRI/2019/08/020716
• Lead Sponsor: Dr Nithya P R

Brief Summary

Vishada is a Vatananatmaja Vikara. The prime clinical features of Vishada are Sada (psychological fatigue) and Apravruthi (lack of motivation). These symptoms of Vishada resemble the disease depression clinically. According to WHO, depression is expected to become the second leading cause of disability worldwide by 2020. Around 350 million people worldwide suffer from depression. In India around 57 million people (18% of global estimate) suffer from depression. Around 65% youth between the age group 22-25 years shows early signs of depression. Severe depression can lead to suicidal tendency and is responsible for 850,000 deaths per year. 3 15% of the population of most developed countries suffers from severe depression. It remains a social stigma in terms of prevalence, suffering, dysfunction, morbidity and economic burden. If untreated it leads to a complications like Obesity, Diabetes, Alcohol or other drug addiction, Social phobia, Panic disorders, Family conflicts etc. Around 80% of depressed people are not currently having any treatment. Many research studies have found that depression is associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFA) in serum and red blood cell membrane. Atasi is the richest source of α-linolenic acid (ALA) which can be endogenously converted into longer chain of omega-3 polyunsaturated fatty acids. Atasi beeja taila delivers greater amount of omega 3 compared to ground Atasi beeja and the Nasya conducted by using Atasi beeja taila is expected to have direct and instant effect on brain. Blood brain barrier being lipophilic in nature allows the passage of lipids and lipid soluble drugs across it. So here the study plan is to conduct Nasya with Atasi beeja taila in patients suffering from mild to moderate depression.

Nasya karma in the patients of Vishada

Poorva karma – Mukhabhyanga with Murchita taila and Sthanika Swedana.

Pradhana karma – Nasya karma with Atasi beeja taila .

Paschath karma – dhoomapana with Haridra Varthi and monitoring the patient for 7 days

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-08-13
• Study Start: 2019-08-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients diagnosed as per the criteria for mild and moderate depression as per ICD 10.
• Age between 18 to 50 years.
• Patients of either gender, irrespective of socioeconomic status.
• Patients ready to sign informed consent form.

Exclusion Criteria

• Patients with other psychiatric disorders like Schizophrenia, Bipolar mood disorder and substance abuse.
• Patients with severe depressive disorder.
• Pregnant women.
• Patients with other systemic disorders like uncontrolled Hypertension, Diabetes mellitus, Tuberculosis.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effectiveness of Atasi beeja taila nasya in the management of Vishada (mild to moderate depression).	Assessment will be done on baseline, 3rd day and on 7th day

Secondary Outcome Measures

Name	Time	Method
Quality of life	Assessment will be done on baseline, 3rd day and on 7th day

Trial Locations

Locations (1)

Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital; 🇮🇳 Hassan, KARNATAKA, India

Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital

🇮🇳Hassan, KARNATAKA, India

Dr Nithya P R

Principal investigator

9686345190

pg17172@sdmcahhassan.org