NL-OMON53494招募中4 期
Body Weight Adjusted Clopidogrel treatment in patients with CORonary artery Disease (BW-ACCORD) - BW-ACCORD
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •- Patients, male or female, >=18 years of age
- •- Patients treated for coronary artery disease with clopidogrel 75mg QD
- •(aspirin 100mg QD).
- •- Patients must be treated with clopidogrel 75mg for at least one month
- •- Patients must give consent by means of a signed informed consent
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •- Contra-indication for aspirin
- •- Contra-indication for clopidogrel or prasugrel
- •- Occurrence of an ischemic event after PCI or ACS (stroke, myocardial
- •infarction, or coronary revascularization)
- •- Presence of unstable angina complaints.
- •- Presence of two CYP2C19 Loss-of-function (LOF) alleles (*2 or *3)
- •- Scheduled for cardiac valve surgery
- •- Indication for chronic oral anticoagulants
- •- Expected life span of less than one year
- •- Pregnancy
- •- Suboptimal stent placement as determined by the cardiologist.
- •- Patients at increased risk of bleeding with two of the following
- •characteristics: liver cirrhosis with portal hypertension, enhanced bleeding
- •tendency, active malignancy in the past 12 months, thrombocytopenia, major
- •surgery in the past month, spontaneous intracerebral haemorrhage, traumatic
- •intracerebral haemorrhage in the past 12 months, major bleeding requiring
- •hospitalisation or blood transfusion in the past month, ischaemic CVA in the
- •past 5 months.
- •- Known with established stent thrombosis
研究者
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