The effects of rectal administration of SCFA on human substrate and energy metabolism
- Conditions
- impaired fat metabolismoverweight1001842410013317
- Registration Number
- NL-OMON38741
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 13
Overweight/obese men (BMI>=25kg/m2<=35kg/m2)
- Aged 20 - 50 years
- Caucasian
- Normal fasting glucose (NGT: plasma glucose < 6.1 mmol/L)
- Normal blood pressure (systolic blood pressure 100-140mmHg, diastolic blood pressure 60-90 mmHg)
- Weight stable for at least 3 months (± 2kg)
- Type 2 diabetes mellitus (defined as FPG >= 7.0 mmol/l)
- Gastroenterological diseases or abdominal surgery
- Cardiovascular diseases, cancer, liver or kidney malfunction, disease with a life expectancy shorter then 5
years
- Abuse of products
- Plans to lose weight or following of a hypocaloric diet
- Regular supplementation of pre- or probiotic products, use of pre- or probiotics 3 months prior to the start of
the study
- Intensive exercise training more than three hours a week
- Use of any medication that influences glucose or fat metabolism and inflammation (i.e. NSAIDs).
- Regular use of laxative products
- use of antibiotics 3 months prior to the start of the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome parameters are fat oxidation and energy expenditure.<br /><br>The impact of site of administration of SCFA on fat oxidation and energy<br /><br>expenditure will be studied as well as the<br /><br>duration of effect.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Hormones that influence substrate and energy metabolism like Insulin,<br /><br>Glucagon, GLP-1, PYY, FIAF;<br /><br>- Circulating metabolites like Glucose, Free Fatty Acids, Triglycerides;<br /><br>- Inflammatory markers like TNF-a, IL-6, IL-1, Adipokines;<br /><br>- plasma SCFA content<br /><br>- Indirect markers of insulin sensitivity like circulating insulin<br /><br>concentrations;<br /><br>- Appetite (VAS-scoring system).</p><br>