NCT05903963招募中1 期
Evaluation of Renal Protection Of Dexmedetomidine Versus Midazolam As a Sedative For Septic Patients In Intensive Care Unit
Minia University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2023年5月22日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Incidence of acute kidney injury
研究概览
简要总结
Evaluation of Renal Protection Of Dexmedetomidine Versus Midazolam As a Sedative For Septic Patients In Intensive Care Unit
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age (18-80) years old. sex:both male and female.
- •intubated and mechanically ventilated patients.
排除标准
- •1.Patient's relatives refusal.
- •burns as admitting diagnoses. 3.patients with any renal pathology(such as chronic glomerulonephritis, pyelonephritis and diabetic nephropathy).
- •pregnancy or lactation.
- •serious central nervous system pathology (acute stroke, uncontrolled seizures, severe dementia).
- •acute hepatitis or severe liver disease (Child-Pugh class C).
- •unstable angina or acute myocardial infarction, left ventricular ejection fraction less than 30%, heart rate less than 50/min, second- or third-degree heart block, or systolic blood pressure less than 90 mm Hg despite continuous infusions of 2 vasopressors before the start of study drug infusion.
研究组 & 干预措施
Midazolam group
Active Comparator
干预措施: Midazolam (Drug)
dexmedetomidine group
Active Comparator
干预措施: dexmedetomidine (Drug)
结局指标
主要结局
Incidence of acute kidney injury
时间窗: 5 days
urinary kidney injury molecule
次要结局
- length of ICU stay(10 days)
研究者
Marlin Zarif Shehata Yousef
Ass. lecturer of anesthesia and pain medicine
Minia University
研究点 (1)
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