Immunological and Pathological Evaluation of Chronic Fungal Infections of Ski
- Conditions
- Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue
- Registration Number
- CTRI/2021/02/030925
- Lead Sponsor
- Dr Ramesh Bhat M
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
(i)CASES - aged 18 years and above with chronic(defined as â??patients who have
suffered from the disease for at least 6 months duration, in spite of being
treated.â??) and recurrent dermatophytosis (defined as â??occurrence of the dermatophyte infection within few weeks , after completion of treatmentâ??)
Patients willing to give informed consent.
ii)CONTROLS-
aged 18 years and above, who have been successfully treated for
dermatophytosis and newly diagnosed cases of dermatophytosis , after obtaining informed
consent. The non-lesional (normal looking) skin will be selected for biopsy.
iii)Patients willing to give informed consent
(i)Patients aged below 18 years
(ii)Patients who are pregnant
(iii)Patients with superficial dermatophytosis of less than 6 months duration.
(iii) patients without any comorbidity affecting the immune response or
predisposing to dermatophytosis (e.g., primary or secondary
immunosuppression, diabetes mellitus, Cushingâ??s disease, transplant
recipients)
iv)Patients unwilling to give consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Immune cell populations ( cases and controls) through the following immunohistochemical markers will be counted : <br/ ><br>1. CD1 a+ - Langerhan Cells <br/ ><br>2. CD 68 + - Macrophages <br/ ><br>3. Factor XIII a + - Dermal dendrocytes <br/ ><br>Timepoint: At the time of skin biopsy <br/ ><br>
- Secondary Outcome Measures
Name Time Method Comparison of immune cell populations between cases of chronic and recurrent dermatophytosis and controls- treated and cured cases of dermatophytosisTimepoint: At the point of time of biopsy