A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 03
- Conditions
- GastroparesisDiabetes Mellitus
- Interventions
- Drug: Placebo
- Registration Number
- NCT03420781
- Lead Sponsor
- Allergan
- Brief Summary
A 46-week study to compare the efficacy of relamorelin with that of placebo in participants with diabetic gastroparesis (DG). At the end of the 40-week Treatment Period, participants will either continue on relamorelin or placebo for 6 additional weeks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 467
- Participants are eligible to be included in the study only if all the following criteria apply:
- Participant met all inclusion/exclusion criteria of either Protocol RLM-MD-01 (NCT03285308) or Protocol RLM-MD-02 (NCT03426345) and successfully completed the study
- Able to provide written informed consent (IC) prior to any study procedures and willing and able to comply with study procedures
- In the opinion of the investigator, the participant demonstrated adequate compliance with the study procedures in Study RLM-MD-01 or RLM-MD-02
- Participants are excluded from the study if any of the following criteria apply:
- Participant is not willing or able to abide by the restrictions regarding concomitant medicine use
- Participant is planning to receive an investigational drug (other than study treatment) or investigational device at any time during Study RLM-MD-03
- Participant has an unresolved adverse event (AE) or a clinically significant finding on physical examination, clinical laboratory test, or 12-lead electrocardiogram (ECG) that, in the investigator's opinion, would limit the participant's ability to participate in or complete the study
- Any other reason that, in the investigator's opinion, would confound proper interpretation of the study or expose a participant to unacceptable risk, including renal, hepatic or cardiopulmonary disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Randomized Withdrawal Period: Placebo then Relamorelin 10 μg Placebo Participants who received placebo-matching relamorelin injected subcutaneously twice daily for 40 weeks, followed by relamorelin 10 μg injected twice daily for up to 6 weeks in the Randomized Withdrawal (RW) Period. Randomized Withdrawal Period: Relamorelin 10 μg then Placebo Placebo Participants who received relamorelin 10 μg injected subcutaneously twice daily for 40 weeks, followed by placebo-matching relamorelin injected twice daily for up to 6 weeks in the RW Period. Treatment Period: Placebo Placebo Placebo-matching relamorelin injected subcutaneously twice daily for up to 40 weeks. Treatment Period: Relamorelin 10 μg Relamorelin Relamorelin 10 micrograms (μg) injected subcutaneously twice daily for up to 40 weeks. Randomized Withdrawal Period: Relamorelin 10 μg then Placebo Relamorelin Participants who received relamorelin 10 μg injected subcutaneously twice daily for 40 weeks, followed by placebo-matching relamorelin injected twice daily for up to 6 weeks in the RW Period. Randomized Withdrawal Period: Placebo then Relamorelin 10 μg Relamorelin Participants who received placebo-matching relamorelin injected subcutaneously twice daily for 40 weeks, followed by relamorelin 10 μg injected twice daily for up to 6 weeks in the Randomized Withdrawal (RW) Period. Randomized Withdrawal Period: Relamorelin 10 μg then Relamorelin 10 μg Relamorelin Participants who received relamorelin 10 μg injected subcutaneously twice daily for 40 weeks, followed by relamorelin injected twice daily for up to 6 weeks in the RW Period.
- Primary Outcome Measures
Name Time Method Change From Baseline to Week 12 in the Weekly Diabetic Gastroparesis Symptom Severity Score (DGSSS) of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to Week 12 of this study Participants assessed the severity of diabetic gastroparesis symptoms daily using the Diabetic Gastroparesis Symptom Severity Diary (DGSSD), recorded in an electronic diary (e-diary). The DGSSS was derived as the sum of the weekly averages of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0=no or not at all uncomfortable to 10=worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Percentage of Participants Meeting the Vomiting Responder Criterion During Each of the Last 6 Weeks of the First 12-weeks of the Treatment Period Week 6 to Week 12 The number of vomiting episodes in the previous 24 hours were assessed daily by the participant using the DGSSD and were recorded in the e-diary. A Vomiting Responder was defined as a participant with zero weekly vomiting episodes during each of the last 6 weeks of the first 12-weeks of the 40-week Treatment Period.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Meeting the Nausea Responder Criterion During Each of the Last 6 Weeks of the First 12-weeks of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 6 to Week 12) A Nausea Responder was defined as a participant with improvement (decrease) of at least 2-points in the weekly symptom scores for nausea at each of the last 6 weeks of the first 12-weeks of the 40-week Treatment Period. Nausea was one of the items of the DGSSD assessed daily and recorded in the e-diary by the participant using an 11-point ordinal scale where: 0=no nausea to 10=worst possible nausea. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Percentage of Participants Meeting the Abdominal Pain Responder Criterion During Each of the Last 6 Weeks of the First 12-weeks of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 6 to Week 12) An Abdominal Pain Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for abdominal pain at each of the last 6 weeks of the first 12-weeks of the 40-week Treatment Period. Abdominal pain was one of the items of the DGSSD assessed daily and recorded in the e-diary by the participant using an 11-point ordinal scale where: 0=no abdominal pain to 10=the worst possible abdominal pain and was recorded in an e-diary. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Percentage of Participants Meeting the Bloating Responder Criterion During Each of the Last 6 Weeks of the First 12-weeks of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 6 to Week 12) A Bloating Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for bloating at each of the last 6 weeks of the first 12-weeks of the 40-week Treatment Period. Bloating was one of the items of the DGSSD assessed daily and recorded by the participant in the e-diary using an 11-point ordinal scale where: 0=no bloating and 10=the worst possible bloating and was recorded in the e-diary. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Percentage of Participants Meeting the Postprandial Fullness Responder Criterion During Each of the Last 6 Weeks of the First 12-weeks of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 6 to Week 12) A Postprandial Fullness Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for Postprandial Fullness at each of the last 6 weeks of the first 12-weeks of the 40-week Treatment Period. Postprandial Fullness was one of the items of the DGSSD assessed daily and recorded by the participant in the e-diary using an 11-point ordinal scale where: 0=no feeling of fullness until finishing a meal (best) to 10=feeling full after only a few bites (worst). Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Change From Baseline to Week 40 in the Average Weekly DGSSS of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 37 to Week 40) Participants assessed the severity of diabetic gastroparesis symptoms daily using the DGSSD, recorded in an e-diary. The DGSSS was derived as the sum of the weekly averages (Week 37 to Week 40) of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0=no or not at all uncomfortable to 10=worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period of the previous studies.
Percentage of Participants Meeting the Vomiting Responder Criterion at Week 40 of the Treatment Period Week 37 to Week 40 The number of vomiting episodes in the previous 24 hours were assessed daily by the participant using the DGSSD and were recorded in the e-diary. A Vomiting Responder was defined as a participant with zero weekly vomiting episodes during the last 4 weeks of the 40-week Treatment Period.
Change From Baseline to Week 40 in the Average Weekly Number of Vomiting Episodes of the Treatment Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 37 to Week 40) The number of vomiting episodes in the previous 24 hours were assessed daily by the participant using the DGSSD and were recorded in the e-diary. The average weekly number of vomiting episodes were derived as the average of the weekly number of vomiting episodes in the last 4 weeks of the 40-week Treatment Period. A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Change From Baseline to Week 46 in the Average Weekly DGSSS of the Randomized-Withdrawal Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 41 to Week 46) Participants assessed the severity of diabetic gastroparesis symptoms daily using the DGSSD, recorded in an e-diary. The DGSSS was derived as the sum of the weekly averages of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0=no or not at all uncomfortable to 10=worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). Average weekly scores are derived as the average of the weekly scores from the 6 weeks of the RW Period. A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Change From Baseline to Week 46 in the Average Weekly Number of Vomiting Episodes of the Randomized-Withdrawal Period Baseline (14-day Run-in Period of the previous relamorelin study RLM-MD-01 or RLM-MD-02) to (Week 41 to Week 46) The number of vomiting episodes in the previous 24 hours were assessed daily by the participant using the DGSSD and were recorded in the e-diary. Average weekly number of vomiting episodes are derived as the average of the weekly number of vomiting episodes from the six weeks of the RW Period. A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period in the previous studies.
Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAE) First dose of study drug to within 30 days of the last dose of study drug (Up to approximately 50 weeks) An adverse event (AE) is any untoward medical occurrence in a patient or clinical study participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of study treatment. A TEAE is an AE that begins or worsens after receiving study drug.
Number of Participants With Potential Clinically Significant (PCS) Clinical Laboratory Results Up to 46 weeks Clinical Laboratory values included Hematology, Chemistry and Urinalysis tests. The investigator determined if the results were clinically significant. Only those categories where at least 1 person had a non-PCS value at Baseline and met the PCS criterion at least once during postbaseline are reported.
Number of Participants With Clinically Meaningful Trends for Vital Signs Up to 46 weeks Vital Signs included assessments of heart rate, respiratory rate, systolic and diastolic blood pressure, and body temperature. The investigator determined if the results were clinically significant.
Number of Participants With Clinically Significant Abnormal Electrocardiogram (ECG) Results Up to 46 weeks A standard 12-lead ECG was performed. The investigator determined if the abnormal results were clinically significant.
Number of Participants With a ≥1% Increase in Glycosylated Hemoglobin A1c (HBA1c) Up to 46 weeks Number of Participants With Anti-relamorelin Antibody Testing Results Up to 46 weeks A blood sample was collected that was sent to a laboratory for an anti-relamorelin antibody screening test. A positive screening test was confirmed by an immunodepletion assay.
Trial Locations
- Locations (332)
Gastroenterology Associates of Fairfield County, P.C.
🇺🇸Bridgeport, Connecticut, United States
Applied Research Center of Arkansas
🇺🇸Little Rock, Arkansas, United States
Kindred Medical Institute for Clinical Trials, LLC
🇺🇸Corona, California, United States
Om Research LLC
🇺🇸Lancaster, California, United States
Arkansas Gastroenterology
🇺🇸North Little Rock, Arkansas, United States
Aurora Care Clinic, LLC
🇺🇸Costa Mesa, California, United States
GW Research Inc
🇺🇸Chula Vista, California, United States
Preferred Research Partners, Inc.
🇺🇸Little Rock, Arkansas, United States
Diagnamics Inc.
🇺🇸Encinitas, California, United States
Torrance Clinical Research Institute, Inc.
🇺🇸Lomita, California, United States
Alabama Medical Group, PC
🇺🇸Mobile, Alabama, United States
Panax Clinical Research, LLC.
🇺🇸Miami Lakes, Florida, United States
Upland Clinical Research
🇺🇸Upland, California, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Savin Medical Group LLC
🇺🇸Miami Lakes, Florida, United States
TrialSpark, Inc.
🇺🇸Washington, District of Columbia, United States
ALL Medical Research LLC
🇺🇸Cooper City, Florida, United States
Synexus
🇺🇸Pinellas Park, Florida, United States
Kansas Medical Clinic
🇺🇸Topeka, Kansas, United States
Innovative Research of West FL, Inc.
🇺🇸Clearwater, Florida, United States
West Central Gastroenterology
🇺🇸Clearwater, Florida, United States
Synexus Clinical Research US, Inc. - Colorado Springs Family Practice
🇺🇸Colorado Springs, Colorado, United States
Gwinnett Research Institute, LLC
🇺🇸Buford, Georgia, United States
MediSphere Medical Research Center, LLC
🇺🇸Evansville, Indiana, United States
Cotton-O'Neil Clinical Research Center - Digestive Health
🇺🇸Topeka, Kansas, United States
Rocky Mountain Diabetes and Osteoporosis Center, PA
🇺🇸Idaho Falls, Idaho, United States
Premier Clinical Research d.b.a. STAT Research
🇺🇸Franklin, Ohio, United States
Infinite Clinical Trials
🇺🇸Riverdale, Georgia, United States
PMG Research Salisbury
🇺🇸Salisbury, North Carolina, United States
Dayton Gastroenterology, Inc.
🇺🇸Beavercreek, Ohio, United States
Aa Mrc Llc
🇺🇸Flint, Michigan, United States
Professional Research Network of Kansas, LLC
🇺🇸Wichita, Kansas, United States
New Orleans Research Institute - Metropolitan Gastroenterology Associates
🇺🇸Metairie, Louisiana, United States
Vida Clinical Studies
🇺🇸Dearborn, Michigan, United States
AGA Clinical Research Associates LLC
🇺🇸Egg Harbor Township, New Jersey, United States
Clinical Research Institute of Michigan
🇺🇸Chesterfield, Michigan, United States
Garden State Endocrinology
🇺🇸Brick, New Jersey, United States
National Clinical, LLC
🇺🇸Hamtramck, Michigan, United States
United Health Services Hospitals, Inc.
🇺🇸Johnson City, New York, United States
ClinRx Research, LLC
🇺🇸Carrollton, Texas, United States
CIC America Clinical Inquest Center Ltd.
🇺🇸Dayton, Ohio, United States
Gastroenterology Associates, PA
🇺🇸Greenville, South Carolina, United States
Synexus Clinical Research US, Inc
🇺🇸Anderson, South Carolina, United States
Advanced Clinical Research
🇺🇸West Jordan, Utah, United States
Montgomery Medical, Inc.
🇺🇸Smithfield, Pennsylvania, United States
Frontier Clinical Research, LLC
🇺🇸Smithfield, Pennsylvania, United States
UMHAT - Kaspela- EOOD
🇧🇬Plovdiv, Bulgaria
KRH Klinikum Siloah
🇩🇪Hannover, Germany
IPEC-Instituto de Pesquisa Clinica
🇧🇷Sao Paulo, Brazil
Life Care Hospital & Research Centre
🇮🇳Bangalore, Karnataka, India
Sociedad de Metabolismo y Corazon, S.C.
🇲🇽Veracruz, Mexico
Communal Institution Kherson City Clinical Hospital
🇺🇦Kherson, Ukraine
Communal Institution "Odesa Regional Clinical Hospital", Out-patient department
🇺🇦Odesa, Ukraine
Royal Oldham Hospital
🇬🇧Oldham, Lancashire, United Kingdom
Kyiv clinical hospital on railway transport #2 of the "Healthcare Centre" branch of JSC "Ukrainian Railway"
🇺🇦Kyiv, Ukraine
MAC Clinical Research Manchester
🇬🇧Manchester, Greater Manchester, United Kingdom
MAC Clinical Research, GAC House
🇬🇧Stockton-on-Tees, United Kingdom
MAC Clinical Research, Monarch House
🇬🇧Leeds, West Yorkshire, United Kingdom
MAC Research
🇬🇧Barnsley, United Kingdom
MAC Clinical Research
🇬🇧Liverpool, United Kingdom
Saratov City Clinical Hospital 12
🇷🇺Saratov, Russian Federation
State Institution Ukrainian State Research Institute of Medical and Social Problems of Disability of the Ministry of Health of Ukraine
🇺🇦Dnipro, Ukraine
MAC Clinical Research, Kaman Court
🇬🇧Blackpool, United Kingdom
Kovai Diabetes Speciality Centre
🇮🇳Coimbatore, Tamil Nadu, India
Avant Research Associates,LLC
🇺🇸Austin, Texas, United States
Frederick Gastroenterology Associates, PA an Elligo Health Research Site
🇺🇸Frederick, Maryland, United States
Trialspark - Silverman
🇺🇸Bowie, Maryland, United States
Meridian Clinical Research, LLC
🇺🇸Rockville, Maryland, United States
AMPM Research Clinic
🇺🇸Miami, Florida, United States
Atlanta Diabetes Associates
🇺🇸Atlanta, Georgia, United States
Emory University
🇺🇸Atlanta, Georgia, United States
Aventiv Research, Inc.
🇺🇸Columbus, Ohio, United States
Biopharma Informatic Inc., Research Center
🇺🇸Houston, Texas, United States
Amir Ali Hassan, MD, PA
🇺🇸Houston, Texas, United States
Rodriguez Clinical Trials
🇺🇸Houston, Texas, United States
Medical Associates Research Group, Inc
🇺🇸San Diego, California, United States
Clinical Research of South Nevada
🇺🇸Las Vegas, Nevada, United States
Synexus Clinical Research US - Cincinnati
🇺🇸Cincinnati, Ohio, United States
Medical Center Universal Clinic Oberig
🇺🇦Kyiv, Ukraine
Regional muniRegional municipal institution "Chernivtsi's regional clinical hospital", gastroenterological department, Higher state educational establishment of Ukraine "Bukovinian state medical university", department of internal medicine and infectious
🇺🇦Chernivtsi, Ukraine
6th City Clinical Hospital, c. Zaporizhzhia
🇺🇦Zaporizhzhia, Ukraine
Regional Public Organization "Chernivtsi Regional Endocrinology Center"
🇺🇦Chernivtsi, Ukraine
Municipal Institution, City Hospital #7
🇺🇦Zaporizhzhia, Ukraine
Centro de Pesquisa Clinica do Brasil
🇧🇷Brasilia, Distrito Federal, Brazil
Arthur Asirvatham Hospital
🇮🇳Madurai, Tamil Nadu, India
Marudhar Hospital
🇮🇳Jaipur, Rajasthan, India
S.R. Kalla (SRK) Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Diabetic Thyroid and Endocrine Centre
🇮🇳Jaipur, Rajasthan, India
Núcleo de Pesquisa Clínica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Eternal Hospital - Diabetology
🇮🇳Jaipur, Rajasthan, India
West Virginia University
🇺🇸Morgantown, West Virginia, United States
Synexus Clinical Research US, Inc.
🇺🇸San Antonio, Texas, United States
Quality Medical Research
🇺🇸Nashville, Tennessee, United States
Pinnacle Clinical Research
🇺🇸San Antonio, Texas, United States
Clinical Trials of Texas, Inc.
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC
🇺🇸San Antonio, Texas, United States
Phoenix Clinical LLC.
🇺🇸Phoenix, Arizona, United States
Digestive Disease Specialists Inc
🇺🇸Oklahoma City, Oklahoma, United States
Memorial Clinical Research
🇺🇸Oklahoma City, Oklahoma, United States
Montana Medical Research
🇺🇸Missoula, Montana, United States
University of California San Diego
🇺🇸La Jolla, California, United States
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Sir Ganga Ram Hospital
🇮🇳New Delhi, India
Hospital Sultanah Bahiyah
🇲🇾Alor Setar, Kedah, Malaysia
Instituto de Investigaciones Clinicas de Rosario
🇦🇷Rosario, Santa Fe, Argentina
Universitair Ziekenhuis Antwerpen, Gastro-Enterologie,
🇧🇪Edegem, Antwerp, Belgium
Mentrials SA DE CV
🇲🇽Cuauhtemoc, Cdmx, Mexico
Centro de Investigación y Atención de Diabetes - Endocrinología y Nutrición
🇲🇽Durango, Guillermina, Mexico
B. J. Government Medical College and Sassoon General Hospitals
🇮🇳Pune, Maharashtra, India
Medplus Medicina Prepagada
🇨🇴Bogota, Distrito Capital De Bogota, Colombia
Kumudini Devi Diabetes Research Center; Ramdevrao Hospital
🇮🇳Hyderabad, Andhra Pradesh, India
Centro de Atención e Investigación en Factores de Riesgo Car
🇲🇽Mexico, Mexico DF, Mexico
Faculty of Medicine, Siriraj Hospital, Mahidol University
🇹🇭Bangkok, Thailand
Synexus Helderberg Clinical Research Centre
🇿🇦Cape Town, Western Cape, South Africa
Fundacion Centro de Investigaciones Clinicas CARDIOMET
🇨🇴Pereira, Risaralda, Colombia
Bhatia Hospital
🇮🇳Mumbai, Maharashtra, India
Centro Cardiovascular y de Diabetes
🇨🇴Barranquilla, Atlantico, Colombia
IPS Centro Medico Julian Coronel S.A
🇨🇴Cali, Valle Del Cauca, Colombia
National University Hospital
🇸🇬Singapore, Singapore
Changi General Hospital
🇸🇬Singapore, Singapore
MAC Research, Exchange House
🇬🇧Cannock, Staffordshire, United Kingdom
Rajalakshmi Hospital
🇮🇳Bengaluru, Karnataka, India
Universal Hospital
🇮🇳Pune, Maharashtra, India
Universiti Sains Malaysia
🇲🇾Kubang Kerian, Malaysia
Consultorio Medico
🇲🇽Guadalajara, Jalisco, Mexico
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Methodist Physicians Clinic Diabetes and Endocrine Specialists
🇺🇸Omaha, Nebraska, United States
Heartland Clinical Research, Inc
🇺🇸Omaha, Nebraska, United States
First Department of Medicine, University of Szeged
🇭🇺Szeged, Csonfrád, Hungary
PMG Research of Wilmington, LLC
🇺🇸Wilmington, North Carolina, United States
Vida Clinical Trials
🇺🇸Homestead, Florida, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
APF Research LLC
🇺🇸Miami, Florida, United States
Advanced Medical Research Institute
🇺🇸Miami, Florida, United States
Asheville Gastroenterology Associates
🇺🇸Asheville, North Carolina, United States
Florida Research Center, Inc.
🇺🇸Miami, Florida, United States
Strázsahegy Gyógyszertár Medicina
🇭🇺Budapest, Hungary
Via Christi Clinic, PA
🇺🇸Wichita, Kansas, United States
iResearch Atlanta LLC
🇺🇸Decatur, Georgia, United States
Southwest Gastroenterology
🇺🇸Oak Lawn, Illinois, United States
Clinical Trials of America, Inc.
🇺🇸West Monroe, Louisiana, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
Excel Clinical Research
🇺🇸Las Vegas, Nevada, United States
Digestive Disease Specialists
🇺🇸Las Vegas, Nevada, United States
Palm Research Center
🇺🇸Las Vegas, Nevada, United States
Cumberland Research Associates, LLC
🇺🇸Fayetteville, North Carolina, United States
Long Island Gastrointestinal Research Group LLP
🇺🇸Great Neck, New York, United States
Triad Clinical Trials
🇺🇸Greensboro, North Carolina, United States
Diabetes & Endocrinology Associates of Stark County, Inc.
🇺🇸Canton, Ohio, United States
The Ohio State University, Wexner Medical Center
🇺🇸Columbus, Ohio, United States
Advanced Research Institute, Inc.
🇺🇸Ogden, Utah, United States
Hometown Urgent Care and Research
🇺🇸Dayton, Ohio, United States
Family Practice Center of Wadsworth, Inc. DBA New Venture Medical Research
🇺🇸Wadsworth, Ohio, United States
Preferred Primary Care Physicians, Inc.
🇺🇸Pittsburgh, Pennsylvania, United States
Family Medical Associates, Research Department
🇺🇸Levittown, Pennsylvania, United States
Allegheny Endocrinology Associates
🇺🇸Pittsburgh, Pennsylvania, United States
Cardinal Internal Medicine Associates, PC
🇺🇸Woodbridge, Virginia, United States
Digestive Health Specialist of the South East
🇺🇸Dothan, Alabama, United States
North Alabama Research Center, LLC
🇺🇸Athens, Alabama, United States
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
G & L Research, LLC
🇺🇸Foley, Alabama, United States
Unity Health - Searcy Medical Center
🇺🇸Searcy, Arkansas, United States
Hope Clinical Research
🇺🇸Canoga Park, California, United States
VVCRD Research
🇺🇸Garden Grove, California, United States
TriWest Research Associates
🇺🇸Poway, California, United States
Angel City Research Inc.
🇺🇸Los Angeles, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
Clinical Research of West Florida
🇺🇸Clearwater, Florida, United States
Palmetto Research, LLC
🇺🇸Hialeah, Florida, United States
Top Medical Research
🇺🇸Cutler Bay, Florida, United States
American Research Institute, Inc
🇺🇸Miami, Florida, United States
River Birch Research Alliance, LLC
🇺🇸Blue Ridge, Georgia, United States
Summit Clinical Research, LLC.
🇺🇸Carnesville, Georgia, United States
Clinical Research Consultants of Atlanta
🇺🇸Suwanee, Georgia, United States
WestGlen Gastrointestinal Consultants
🇺🇸Shawnee Mission, Kansas, United States
American Research, LLC
🇺🇸Jeffersonville, Indiana, United States
Health Science Research Center
🇺🇸Pratt, Kansas, United States
Tri-State Gastroenterology
🇺🇸Crestview Hills, Kentucky, United States
Delta Research Partners
🇺🇸Bastrop, Louisiana, United States
Clinical Trials of SWLA, LLC
🇺🇸Lake Charles, Louisiana, United States
Cronola LLC
🇺🇸Houma, Louisiana, United States
Gastro Center of Maryland
🇺🇸Columbia, Maryland, United States
Woodholme Gastroenterology Associates, P.A.
🇺🇸Glen Burnie, Maryland, United States
Gastroenterology Associates of Western Michigan
🇺🇸Wyoming, Michigan, United States
Minnesota Gastroenterology, P.A.
🇺🇸Coon Rapids, Minnesota, United States
Advanced Biomedical Research of America
🇺🇸Las Vegas, Nevada, United States
Vidant Multispeciality Clinic - Kinston
🇺🇸Kinston, North Carolina, United States
Trial Management Associates, LLC
🇺🇸Wilmington, North Carolina, United States
Diabetes and Endocrinology Consultants, PC
🇺🇸Morehead City, North Carolina, United States
Northwest Gastroenterology Clinic, LLC
🇺🇸Portland, Oregon, United States
Endocrinology Research Associates, Inc.
🇺🇸Columbus, Ohio, United States
Options Health Research, LLC
🇺🇸Tulsa, Oklahoma, United States
Preferred Primary Care Physicians
🇺🇸Uniontown, Pennsylvania, United States
Health Concepts
🇺🇸Rapid City, South Dakota, United States
Clinsearch
🇺🇸Chattanooga, Tennessee, United States
Texas Clinical Research Institute, LLC
🇺🇸Arlington, Texas, United States
Sante Clinical Research
🇺🇸Kerrville, Texas, United States
Verity Research Inc.
🇺🇸Fairfax, Virginia, United States
Washington Gastroenterology PLLC
🇺🇸Tacoma, Washington, United States
Manassas Clinical Research Centre
🇺🇸Manassas, Virginia, United States
Maffei Centro Medico-Investigacion Clinica Aplicada
🇦🇷C.a.b.a., Buenos Aires Province, Argentina
Hospital Sirio Libanes
🇦🇷Caba, Buenos Aires Province, Argentina
Instituto Privado de Investigaciones Clínicas de Córdoba
🇦🇷Córdoba, Cordoba, Argentina
Centro de Investigaciones Medicas Mar del Plata
🇦🇷Mar del Plata, Buenos Aires Province, Argentina
Instituto de Hematologia y Medicina Clinica Dr. Ruben Davoli
🇦🇷Rosario, Santa Fe, Argentina
Clinica Mayo de Urgencias Medicas Cruz Blanca SRL
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Centro Universitario de Investigacion en Farmacologia Clinic
🇦🇷Corrientes, Argentina
CIPREC
🇦🇷Ciudad Autonoma de Buenos Aires, Argentina
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
VIVIT Institute, am LKH Feldkirch
🇦🇹Feldkirch', Vorarlberg, Austria
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Ordination
🇦🇹Sankt Stefan ob Stainz, Styria, Austria
Landeskrankenhaus Steyr
🇦🇹Steyr, Austria
Privatklinik Wehrle-Diakonissen
🇦🇹Salzburg, Austria
UZ Brussel
🇧🇪Jette, Brussel, Belgium
Instituto de Estudos e Pesquisas Clinicas do Ceará IEP/CE - Oncology
🇧🇷Fortaleza, Ceará, Brazil
Hospital Universitário Walter Cantídio
🇧🇷Fortaleza, Ceara, Brazil
Scentryphar Pesquisa Clinica Ltda
🇧🇷Campinas, Sao Paulo, Brazil
Instituto Catarinense de Endocrinologia e Diabetes (ICED)
🇧🇷Joinville, Santa Catarina, Brazil
MHAT Yuliya Vrevska Byala
🇧🇬Byala, Ruse, Bulgaria
CPQuali Pesquisa Clinica Ltda
🇧🇷Santa Cecília, São Paulo, Brazil
Instituto de Pesquisa Clinica de Campinas
🇧🇷Campinas, Sao Paulo, Brazil
Hospital Universitário João de Barros Barreto
🇧🇷Belém, Brazil
Toronto Digestive Disease Associates
🇨🇦Vaughan, Ontario, Canada
University of Calgary
🇨🇦Calgary, Alberta, Canada
Central Alberta Research Centre
🇨🇦Red Deer, Alberta, Canada
South Shore Medical Arts
🇨🇦Bridgewater, Nova Scotia, Canada
The Ottawa Hospital
🇨🇦Ottawa, Ontario, Canada
Recherche GCP Research
🇨🇦Montreal, Quebec, Canada
Fundacion BIOS
🇨🇴Barranquilla, Atlantico, Colombia
Rodrigo Botero S.A.S.
🇨🇴Medellín, Antioquia, Colombia
Centro Cardiovascular Colombiano Clínica Santa María
🇨🇴Medellin, Antioquia, Colombia
Endocare Ltda.
🇨🇴Bogotá, Cundinamarca, Colombia
Centro Medico Imbanaco de Cali S.A.
🇨🇴Cali, Valle Del Cauca, Colombia
Asociación Colombiana de Diabetes
🇨🇴Teusaquillo, Distrito Capital De Bogotá, Colombia
Healthy Medical Center
🇨🇴Zipaquirá, Cundinamarca, Colombia
Studienzentrum Schwittay
🇩🇪Böhlen, Saxony, Germany
Gentofte Hospital
🇩🇰Hellerup, Copenhagen, Denmark
Gastroenheden, Hvidovre hospital
🇩🇰Hvidovre, Copenhagen, Denmark
Klinische Forschung Karlsruhe GmbH
🇩🇪Karlsruhe, Baden-Wuertemberg, Germany
Klinische Forschung Dresden GmbH
🇩🇪Dresden, Saxony, Germany
Clinical Research Hamburg
🇩🇪Hamburg, Germany
Israelitisches Krankenhaus
🇩🇪Hamburg, Germany
Hetenyi Geza Hospital
🇭🇺Tószeg, Jász-Nagykun-Szolnok, Hungary
Synexus Budapest DRS
🇭🇺Budapest, Hungary
Zala Megyei Szent Rafael Korhaz
🇭🇺Zalaegerszeg, Zala, Hungary
Markhot Ferenc Oktatokorhaz es Rendelointezet
🇭🇺Eger, Heves, Hungary
King George Hospital
🇮🇳Visakhapatnam, Andhra Pradesh, India
Dr. Jivraj Mehta Smarak Health Foundation, Bakeri Medical Research Centre
🇮🇳Ahmedabad, Gujarat, India
Diacon Hospital and research Center - Diabetology
🇮🇳Bengaluru, Karnataka, India
Victoria Hospital
🇮🇳Bangalore, Karnataka, India
Vinaya Hospital & Research Centre
🇮🇳Mangalore, Karnataka, India
Noble Hospital
🇮🇳Pune, Maharashtra, India
SMS Hospital
🇮🇳Jaipur, Rajasthan, India
M. V Hospital & Research Centre
🇮🇳Lucknow, Uttar Prandesh, India
Endocrinology & Diabetes Center
🇮🇱Safed, Israel
Diabetes Center
🇰🇷Seoul, Nowon-gu, Korea, Republic of
Kraslava Hospital
🇱🇻Kraslava, Kraslavas Nov., Latvia
Digestive Diseases Centre GASTRO
🇱🇻Riga, Latvia
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Polana-D
🇱🇻Daugavpils, Latvia
Chonbuk National University Hospital
🇰🇷Jeonju, Jeollabuk-Do, Korea, Republic of
Pauls Stradins Clinical University Hospital, Endokrinologijas nodala
🇱🇻Riga, Latvia
Hospital Taiping
🇲🇾Taiping, Malaysia
Clinicos Asociados BOCM SC
🇲🇽Mexico, Distrito Federal, Mexico
Centro Especializado en Diabetes, Obesidad y Prevencion de E - Endocrinology
🇲🇽Mexico, Distrito Federal, Mexico
Unidad de Investigación Clínica en Medicina S.C.
🇲🇽Guadalajara, Jalisco, Mexico
Dioderm Instituto de Investigacion
🇲🇽Durango, Mexico
Centro de Investigacion Cardiometabolica de Aguascalientes SA de CV
🇲🇽Aguascalientes, Mexico
Hospital Cardiologica Aguascalientes
🇲🇽Aguascalientes, Mexico
West Visayas State University Medical Center
🇵🇭IloIlo City, IloIlo, Philippines
Cardinal Santos Medical Center
🇵🇭San Juan City, Metro Manila, Philippines
Specjalistyczny Gabinet Neurologiczny Marta Banach
🇵🇱Krakow, Poland
Manila Doctors Hospital, Ermita
🇵🇭Manila, Metropolitan Manila, Philippines
Ospital ng Makati
🇵🇭Makati City, NCR, Philippines
San Juan De Dios Educational Foundation, Inc.
🇵🇭Pasay, Metropolitan Manila, Philippines
Perpetual Succor Hospital
🇵🇭Cebu City, Philippines
NZOZ Vita Diabetica - Malgorzata Buraczyk
🇵🇱Bialystok, Podlaski, Poland
Centrum Medyczne Lukamed
🇵🇱Chojnice, Poland
Endoskopia Sp. Z O.O.
🇵🇱Sopot, Pomorskie, Poland
Scientific Institute of Clinical and Experimental Lymphology
🇷🇺Novosibirsk, Novosibirskaya Oblast, Russian Federation
Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska
🇵🇱Wroclaw, Poland
Saint-Petersburg City Pokrovskaya Hospital
🇷🇺St-Petersburg, Leningrad Region, Russian Federation
Nizhegorodsky Regional Clinical Hospital named after N. A. Semashko
🇷🇺Nizhny Novgorod, Volga, Russian Federation
North-Western State Medical University named after I. I. Mechnikov
🇷🇺Saint-Petersburg, Sankt-Peterburg, Russian Federation
FSBI National medical endocrinology research centre
🇷🇺Moscow, Russian Federation
Kazan State Medical University
🇷🇺Kazan, Russian Federation
Rostov on Don
🇷🇺Rostov on Don, Russian Federation
Rostov State Medical University
🇷🇺Rostov-on-Don, Russian Federation
Moscow Regional Research Clinical Institute named by MF Vladimirski
🇷🇺Moscow, Russian Federation
GUZ Saratov City Clinical Hospital 9
🇷🇺Saratov, Russian Federation
Singapore General Hospital
🇸🇬Singapore, Singapore
Wits Clinical Research
🇿🇦Johannesburg, Gauteng, South Africa
Synexus Stanza Clincal Reaserch Centre
🇿🇦Pretoria, Gauteng, South Africa
Watermeyer Clinical Research Site
🇿🇦Pretoria, Gauteng, South Africa
Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Ivano-Frankivsk National Medical University
🇺🇦Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine
Municipal nonprofit entity of Kharkiv municipal council
🇺🇦Kharkiv, Ukraine
Clinical Endocrinology of SI "V.Danilevsky Institute for endocrine pathology problems National Academy of Medical sciences of Ukraine"
🇺🇦Kharkiv, Ukraine
Odessa Railway Clinical Hospital of Branch of HC JSC Ukrzaliznytsia, Odessa National Medical University
🇺🇦Odesa, Ukraine
Polyclinic of medical services and rehabilitation department of State Joint-Stock Holding Company Artem, day-patient unit
🇺🇦Kyiv, Ukraine
Poltava Regional Clinical Hospital
🇺🇦Poltava, Ukraine
Private Small-Scale Enterprise Medical Centre Pulse
🇺🇦Vinnytsia, Ukraine
Ternopil University Hospital
🇺🇦Ternopil, Ukraine
Vinnytsia Regional Clinical highly specialized Endocrinology Centre
🇺🇦Vinnytsia, Ukraine
Municipal nonprofit entity "Vinnytsia's city clinical hospital #1", c. Vinnytsia
🇺🇦Vinnytsia, Ukraine
Biomedical Research Centre
🇬🇧Nottingham, East Midland, United Kingdom
Mid Essex Hospital Services NHS Trust Broomfield Hospital
🇬🇧Chelmsford, United Kingdom
Ivano-Frankivsk Central City Clinical Hospital
🇺🇦Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine
L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine
🇺🇦Kharkiv, Ukraine
Limited Liability Company "Medical and Diagnostic Center "ADONIS Plus", outpatient department, c. Kyiv
🇺🇦Kyiv, Ukraine
AZ Sint Lucas Brugge
🇧🇪Brugge, West-Vlaanderen, Belgium
University of Louisville
🇺🇸Louisville, Kentucky, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
PMG Research of Winston-Salem, LLC
🇺🇸Winston-Salem, North Carolina, United States
The Center for Clinical Research
🇺🇸Winston-Salem, North Carolina, United States
Clinical Trials of South Carolina
🇺🇸Charleston, South Carolina, United States
Centro de Desarrollo Biomédico S.C.P
🇲🇽Mérida, Yucatán, Mexico
Lovelace Scientific Resources, Inc.
🇺🇸Albuquerque, New Mexico, United States
Alberta Diabetes Institute
🇨🇦Edmonton, Alberta, Canada
Avant Research Associates LLC
🇺🇸Crowley, Louisiana, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Commonwealth Clinical Studies, PLLC.
🇺🇸Brockton, Massachusetts, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
WK Physicians Network
🇺🇸Bossier City, Louisiana, United States
St. Luke's Medical Center
🇵🇭Quezon City, Metro Manila, Philippines
FARMOVS
🇿🇦Bloemfontein, Free State, South Africa
Carolina Digestive Health Associates, PA
🇺🇸Concord, North Carolina, United States
Unidad de Investigacion Clinica Cardiometabolica de Occidente, S.C.
🇲🇽Guadalajara, Jalisco, Mexico
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States